Evidence map›Paper›PMID 36437999›Full record

ArticleFrontiers in aging neuroscience2022

Preliminary findings of accelerated visual memory decline and baseline brain correlates in middle-age and older adults with autism: The case for hippocampal free-water.

Melissa J M Walsh, Edward Ofori, Broc A Pagni, Kewei Chen, Georgia Sullivan, B Blair Braden

Open access · goldAbstract read
In one paragraph

Article in Frontiers in aging neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 3 pooled it
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Cognitive and Cerebral Aging Research in Autism: A Systematic Review on an Emerging Topic.Autism research : official journal of the International Society for Autism Research · 2025
    Pooled it
  3. Pooled it
  4. System-Specific Epigenetic Aging Signatures in Autistic Adults.bioRxiv : the preprint server for biology · 2026
    Article
  5. International journal of molecular sciences · 2026
    Review
  6. Article
  7. Article
  8. Decreased BOLD Signal Variability in Middle-Aged and Older Adults on the Autism Spectrum.Autism research : official journal of the International Society for Autism Research · 2026
    Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Article
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  19. Article
  20. International journal of molecular sciences · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Melissa J M WalshCollege of Health Solutions, Arizona State University, Tempe, AZ, United States.
Edward OforiCollege of Health Solutions, Arizona State University, Tempe, AZ, United States.
Broc A PagniCollege of Health Solutions, Arizona State University, Tempe, AZ, United States.
Kewei ChenBanner Alzheimer's Institute, Phoenix, AZ, United States.
Georgia SullivanCollege of Health Solutions, Arizona State University, Tempe, AZ, United States.
B Blair BradenCollege of Health Solutions, Arizona State University, Tempe, AZ, United States.
Arizona State University · USBanner Alzheimer’s Institute

Funding

Research Education ComponentP30AG019610 · NIA · SUN HEALTH RESEARCH INSTITUTE · PI ALEXANDER, GENE E · 2001 to 2020
$32.5M
Research Education ComponentP30AG072980 · NIA · BANNER HEALTH · PI Nicholas Ashton · 2021 to 2026
$24.9M
Sex-Specific Brain and Behavioral Predictors of Cognitive Aging in Middle-Aged Adults with Autism Spectrum DisorderK01MH116098 · NIMH · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI BRADEN, BRITTANY BLAIR · 2018 to 2022
$760k
NIA NIH HHS P30 AG019610NIA NIH HHS P30 AG072980NIMH NIH HHS K01 MH116098
6 · The paper itself

Abstract

Research aimed at understanding cognitive and brain aging in adults with autism spectrum disorder (ASD) is growing, but critical longitudinal work is scant. Adults with ASD struggle with tasks involving visual memory compared with neurotypical adults (NT). This may be related to differences in size or integrity of the hippocampus and its' primary structural connectivity pathway, the fornix. The aim of this study was to describe preliminary findings of longitudinal aging trajectories in short- and long-term visual memory abilities in middle-age and older adults with ASD, compared with matched NT adults. We then evaluated baseline multi-modal imaging metrics of the hippocampal system, including the relatively novel metric of free-water, as potential correlates of longitudinal memory change in the ASD group. Middle-age and older adults with ASD (

Indexed as

agingautismautisticDTIfornixhippocampusmemoryMRI

Identifiers

PMID36437999
PMCPMC9694823
OpenAlexW4308937900

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.