Evidence map›Paper›PMID 36437989›Full record

ArticleFrontiers in aging neuroscience2022

Stability of motor-nonmotor subtype in early-stage Parkinson's disease.

Yi Xiao, Qianqian Wei, Ruwei Ou, Yanbing Hou, Lingyu Zhang, Kuncheng Liu, Junyu Lin, Tianmi Yang, Qirui Jiang, Huifang Shang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in aging neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yi XiaoLaboratory of Neurodegenerative Disorders, Department of Neurology, Rare Disease Center, National Clinical Research Center for Geriatric, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Qianqian WeiLaboratory of Neurodegenerative Disorders, Department of Neurology, Rare Disease Center, National Clinical Research Center for Geriatric, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Ruwei OuLaboratory of Neurodegenerative Disorders, Department of Neurology, Rare Disease Center, National Clinical Research Center for Geriatric, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Yanbing HouLaboratory of Neurodegenerative Disorders, Department of Neurology, Rare Disease Center, National Clinical Research Center for Geriatric, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Lingyu ZhangHealth Management Center, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
Kuncheng LiuLaboratory of Neurodegenerative Disorders, Department of Neurology, Rare Disease Center, National Clinical Research Center for Geriatric, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Junyu LinLaboratory of Neurodegenerative Disorders, Department of Neurology, Rare Disease Center, National Clinical Research Center for Geriatric, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Tianmi YangLaboratory of Neurodegenerative Disorders, Department of Neurology, Rare Disease Center, National Clinical Research Center for Geriatric, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Qirui JiangLaboratory of Neurodegenerative Disorders, Department of Neurology, Rare Disease Center, National Clinical Research Center for Geriatric, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Huifang ShangLaboratory of Neurodegenerative Disorders, Department of Neurology, Rare Disease Center, National Clinical Research Center for Geriatric, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The different clinical characteristics and prognostic values of the motor-nonmotor subtypes of Parkinson's disease (PD) have been established by previous studies. However, the consistency of motor-nonmotor subtypes in patients with early-stage Parkinson's disease required further investigation. The present study aimed to evaluate the consistency of motor-nonmotor subtypes across five years of follow-up in a longitudinal cohort. Materials and methods: Patients were classified into different subtypes (mild-motor-predominant, intermediate, diffuse malignant; or tremor-dominant, indeterminate, postural instability and gait difficulty) according to previously verified motor-nonmotor and motor subtyping methods at baseline and at every year of follow-up. The agreement between subtypes was examined using Cohen's kappa and total agreement. The determinants of having the diffuse malignant subtype as of the fifth-year visit were explored using logistic regression. Results: A total of 421 patients were included. There was a fair degree of agreement between the baseline motor-nonmotor subtype and the subtype recorded at the one-year follow-up visit (κ = 0.30 ± 0.09; total agreement, 60.6%) and at following years' visits. The motor-nonmotor subtype had a lower agreement between baseline and follow-up than did the motor subtype. The baseline motor-nonmotor subtype was the determinant of diffuse malignant subtype at the fifth-year visit. Conclusion: Many patients experienced a change in their motor-nonmotor subtype during follow-up. Further studies of consistency in PD subtyping methods should be conducted in the future.

Indexed as

follow-up studies (MeSH)Parkinson’s diseaseprognosisstabilitysubtype

Identifiers

PMID36437989
PMCPMC9686273

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