ArticleHuman brain mapping2023
Multisite test-retest reliability and compatibility of brain metrics derived from FreeSurfer versions 7.1, 6.0, and 5.3.
Article in Human brain mapping, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Genetic insights into human cortical organization and development through genome-wide analyses of 2,347 neuroimaging phenotypes.Nature genetics · 2023Pooled it
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- Hippocampal volume and white matter impairments in patients with congenital adrenal hyperplasia.The Journal of clinical endocrinology and metabolism · 2026Article
- Experience-dependent cortical plasticity in response to formal schooling: Effects on networks for reading and mathematics.Developmental cognitive neuroscience · 2026Article
- Multi-threshold polygenic risk improves hippocampal-based cognitive decline prediction.Genome medicine · 2026Article
- Test-retest reliability of FreeSurfer measures of neurodegeneration.NeuroImage · 2026Article
- Subcortical brain structures among maltreated youth with high and low externalizing problems.European child & adolescent psychiatry · 2026Article
- Charting brain morphology in international healthy and neurological populations.Nature neuroscience · 2026Article
- The impact of balance exercise on brain age and brain morphometry: insights from MRI analysis.Aging clinical and experimental research · 2026Observational
- Convergent structural brain alterations in chronic pain: a multi-metric individual participant data meta-analysis.Brain communications · 2026Article
- Multi-Cohort Federated Learning Shows Synergy in Mortality Prediction for MRI-Based and Metabolomics-Based Age Scores.Journal of healthcare informatics research · 2025Article
- Quantifying brain atrophy in Frontotemporal Dementia: a head-to-head comparison of neuroimaging techniques.medRxiv : the preprint server for health sciences · 2025Article
- 3D Morphometric and Computational Modeling of the Human Fasciola Cinerea: A Hidden Gate of Memory Networks.Neuroinformatics · 2025Article
- A FastSurfer Database for Age-Specific Brain Volumes in Healthy Children: A Tool for Quantifying Localized and Global Brain Volume Alterations in Pediatric Patients.Brain and behavior · 2025Article
- Pattern of Deep Grey Matter Undersizing Boosts MRI-Based Diagnostic Classifiers in Fetal Alcohol Spectrum Disorders.Human brain mapping · 2025Article
- Regional abnormalities in the hippocampus and verbal memory impairment in craniofacial dystonia.Frontiers in neuroscience · 2025Article
- Challenges in measuring individual differences of brain function.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Current best practices and future opportunities for reproducible findings using large-scale neuroimaging in psychiatry.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Review
- Caudate nucleus volume in medicated and unmedicated patients with early- and adult-onset schizophrenia.Scientific reports · 2024Article
- FreeSurfer version-shuffling can enhance brain age predictions.Neuroimage. Reports · 2024Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Automatic neuroimaging processing tools provide convenient and systematic methods for extracting features from brain magnetic resonance imaging scans. One tool, FreeSurfer, provides an easy-to-use pipeline to extract cortical and subcortical morphometric measures. There have been over 25 stable releases of FreeSurfer, with different versions used across published works. The reliability and compatibility of regional morphometric metrics derived from the most recent version releases have yet to be empirically assessed. Here, we used test-retest data from three public data sets to determine within-version reliability and between-version compatibility across 42 regional outputs from FreeSurfer versions 7.1, 6.0, and 5.3. Cortical thickness from v7.1 was less compatible with that of older versions, particularly along the cingulate gyrus, where the lowest version compatibility was observed (intraclass correlation coefficient 0.37-0.61). Surface area of the temporal pole, frontal pole, and medial orbitofrontal cortex, also showed low to moderate version compatibility. We confirm low compatibility between v6.0 and v5.3 of pallidum and putamen volumes, while those from v7.1 were compatible with v6.0. Replication in an independent sample showed largely similar results for measures of surface area and subcortical volumes, but had lower overall regional thickness reliability and compatibility. Batch effect correction may adjust for some inter-version effects when most sites are run with one version, but results vary when more sites are run with different versions. Age associations in a quality controlled independent sample (N = 106) revealed version differences in results of downstream statistical analysis. We provide a reference to highlight the regional metrics that may yield recent version-related inconsistencies in published findings. An interactive viewer is provided at http://data.brainescience.org/Freesurfer_Reliability/.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.