Evidence map›Paper›PMID 36437393›Full record

SynthesisNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2023

New use for an old drug: quinidine in KCNT1-related epilepsy therapy.

Ru Liu, Lei Sun, Yunfu Wang, Qun Wang, Jianping Wu

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Reduction ofFrontiers in neuroscience · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Ru LiuHubei Key Laboratory of Nanomedicine for Neurodegenerative Diseases, School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, 122 Loushi Rd, Wuhan, 430070, China.
Lei SunDepartment of Neurology, Henan Provincial People's Hospital, Zhengzhou University People's Hospital, Henan University People's Hospital, Zhengzhou, 450008, Henan, China.
Yunfu WangHubei Key Laboratory of Embryonic Stem Cell Research, Hubei University of Medicine, Shiyan, 442000, China.
Qun WangBeijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.
Jianping WuHubei Key Laboratory of Nanomedicine for Neurodegenerative Diseases, School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, 122 Loushi Rd, Wuhan, 430070, China. biojpwu@gmail.com.ORCID http://orcid.org/0000-0002-2684-6122
Capital Medical University · CNHubei University of Medicine · CNZhengzhou University · CN

Funding

National Natural Science Foundation of China 81870935Wuhan University of Technology 40122070
6 · The paper itself

Abstract

KCNT1 has been known to encode a subunit of the tetrameric sodium activated potassium channel (K

Indexed as

EpilepsyQuinidineAnticonvulsantsHumansMutationNerve Tissue ProteinsPotassium ChannelsPotassium Channels, Sodium-ActivatedAnticonvulsantsKCNT1 protein, humanNerve Tissue ProteinsPotassium ChannelsPotassium Channels, Sodium-ActivatedQuinidineKCNT1-related epilepsyKNa1.1Phenotype-genotype associationsQuinidine

Identifiers

PMID36437393
OpenAlexW4310170686

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.