Evidence map›Paper›PMID 36437392›Full record

ArticleFamilial cancer2023

A retrospective cohort study of genetic referral and diagnosis of Lynch syndrome in patients with cutaneous sebaceous lesions.

Meera Kattapuram, Christina Shabet, Sarah Austin, Michelle F Jacobs, Erika Koeppe, Emily H Smith, Lori Lowe, Tobias Else, Kelly B Cha

Abstract read
PubMed Publisher
In one paragraph

Article in Familial cancer, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Meera KattapuramUniversity of Michigan Medical School, Ann Arbor, MI, USA.
Christina ShabetUniversity of Michigan Medical School, Ann Arbor, MI, USA.
Sarah AustinDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
Michelle F JacobsDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
Erika KoeppeDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
Emily H SmithDepartment of Pathology, University of Michigan, Ann Arbor, MI, USA.
Lori LoweDepartment of Pathology, University of Michigan, Ann Arbor, MI, USA.
Tobias Else *Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA. telse@med.umich.edu.
Kelly B Cha *Department of Dermatology, University of Michigan, Ann Arbor, MI, USA.
University of Michigan–Ann Arbor · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immunohistochemistry (IHC) of cutaneous sebaceous lesions (SL) can be used to screen patients for Lynch syndrome (LS). There is little data on rates of genetic referral and outcomes of genetic testing for patients with SL. This single-center retrospective study characterizes 400 + patients with SL, including IHC results, genetics referrals, and outcomes of genetic testing. Retrospective chart reviews were performed for patients with a pathology-confirmed diagnosis of SL at the University of Michigan between January 2009 and December 2019. 447 patients with 473 SL were identified. Excluding 20 patients with known LS, IHC was conducted in 173 (41%) patients. 92/173 (53%) patients had abnormal results. 69 of these 92 (75%) patients were referred to genetics. 32 additional patients were referred with normal IHC (n = 22) or without IHC (n = 10). Of 101 patients referred, 65 (64%) were seen and 47 (47%) completed genetic testing. 7/47 (15%) had pathogenic variants associated with LS, six with concordant abnormal IHC and one without IHC. Cancer genetics referral of patients with SL, particularly for lesions with abnormal IHC, yields a significant rate of LS diagnosis. Providers should consider genetics referral for patients with SL.

Indexed as

Colorectal Neoplasms, Hereditary NonpolyposisDNA Mismatch RepairGenetic TestingGerm-Line MutationHumansReferral and ConsultationRetrospective StudiesGenetic testingImmunohistochemistryLynch syndromeMuir-Torre syndromeSebaceous lesions

Identifiers

PMID36437392
OpenAlexW4310028522

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.