ArticleMolecular psychiatry2024
Ventral tegmental area glutamate neurons mediate nonassociative consequences of stress.
Article in Molecular psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 21 citations in OpenAlex.
- Mesohabenular glutamatergic regulation of the consequences of uncontrollable stress.bioRxiv : the preprint server for biology · 2026Article
- Disrupted synapses: prefrontal cortex-reward circuit dysfunction in stress-induced depression-like behaviors.Frontiers in cellular neuroscience · 2026Review
- Effects of GPR110 expression on neurobehavioral outcomes in mice.Frontiers in neuroscience · 2026Article
- Untangling the multifaceted VTA responses to stress.Trends in neurosciences · 2025Review
- Salience Signaling and Stimulus Scaling of Ventral Tegmental Area Glutamate Neuron Subtypes.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- A midbrain circuit mechanism for noise-induced negative valence coding.Nature communications · 2025Article
- Assessing the role of BNST GABA neurons in backward conditioned suppression.Neurobiology of learning and memory · 2025Article
- Untangling dopamine and glutamate in the ventral tegmental area.bioRxiv : the preprint server for biology · 2025Article
- Monosynaptic Inputs to Ventral Tegmental Area Glutamate and GABA Co-transmitting Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- A suite of enhancer AAVs and transgenic mouse lines for genetic access to cortical cell types.bioRxiv : the preprint server for biology · 2024Article
- Mesoaccumbal glutamate neurons drive reward via glutamate release but aversion via dopamine co-release.Neuron · 2024Article
- Stress-induced anxiety-related behavior in mice is driven by enhanced excitability of ventral tegmental area GABA neurons.Frontiers in behavioral neuroscience · 2024Article
- Ventral tegmental area glutamate neurons establish a mu-opioid receptor gated circuit to mesolimbic dopamine neurons and regulate opioid-seeking behavior.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Spatial transcriptomic analysis of the mouse brain following chronic social defeat stress.Exploration (Beijing, China) · 2023Article
- Bed nucleus of the stria terminalis GABA neurons are necessary for changes in foraging behaviour following an innate threat.The European journal of neuroscience · 2023Article
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Authors and funding
13 authors at 4 institutions in 1 country.
Funding
Abstract
Exposure to trauma is a risk factor for the development of a number of mood disorders, and may enhance vulnerability to future adverse life events. Recent data demonstrate that ventral tegmental area (VTA) neurons expressing the vesicular glutamate transporter 2 (VGluT2) signal and causally contribute to behaviors that involve aversive or threatening stimuli. However, it is unknown whether VTA VGluT2 neurons regulate transsituational outcomes of stress and whether these neurons are sensitive to stressor controllability. This work adapted an operant mouse paradigm to examine the impact of stressor controllability on VTA VGluT2 neuron function as well as the role of VTA VGluT2 neurons in mediating transsituational stressor outcomes. Uncontrollable (inescapable) stress, but not physically identical controllable (escapable) stress, produced social avoidance and exaggerated fear in male mice. Uncontrollable stress in females led to exploratory avoidance of a novel brightly lit environment. Both controllable and uncontrollable stressors increased VTA VGluT2 neuronal activity, and chemogenetic silencing of VTA VGluT2 neurons prevented the behavioral sequelae of uncontrollable stress in male and female mice. Further, we show that stress activates multiple genetically-distinct subtypes of VTA VGluT2 neurons, especially those that are VGluT2+VGaT+, as well as lateral habenula neurons receiving synaptic input from VTA VGluT2 neurons. Our results provide causal evidence that mice can be used for identifying stressor controllability circuitry and that VTA VGluT2 neurons contribute to transsituational stressor outcomes, such as social avoidance, exaggerated fear, or anxiety-like behavior that are observed within trauma-related disorders.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.