Evidence map›Paper›PMID 36437124›Full record

ArticleBritish journal of anaesthesia2023

Perioperative ischaemic brain injury and plasma neurofilament light: a secondary analysis of two prospective cohort studies.

Jennifer Taylor, Laura Eisenmenger, Heidi Lindroth, James Booth, Rosaleena Mohanty, Veena Nair, Margaret Parker, David Kunkel, Cameron Rivera, Cameron Casey and 8 more

2 registry-linked trialsOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of anaesthesia, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01980511 completednot on this map

Detection and Neurological Impact of CerebroVascular Events In Noncardiac Surgery PatIents: A COhort EvaluatioN

TypeobservationalSponsorMcMaster UniversityRan2014 to 2018Enrolled1,116ConditionsCovert Postoperative Stroke
NCT03124303 recruitingnot on this map

Interventions for Postoperative Delirium: Biomarker-3

TypeobservationalSponsorUniversity of Wisconsin, MadisonRan2017 to 2029Enrolled468ConditionsDeliriumArmsHigh Density-Electroencephalogram, Magnetic Resonance Imaging, Blood specimen collection, Pupillometry
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Observational
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 8 institutions in 5 countries.

Jennifer TaylorSpecialty of Anaesthetics, Faculty of Medicine and Health, University of Sydney, Sydney, Australia; Department of Anaesthetics, Royal Prince Alfred Hospital, Sydney Local Health District, Camperdown, NSW, Australia.
Laura EisenmengerDepartment of Radiology, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.
Heidi LindrothDivision of Nursing Research, Mayo Clinic, Rochester, MN, USA.
James BoothDepartment of Anaesthetics, Royal Prince Alfred Hospital, Sydney Local Health District, Camperdown, NSW, Australia.
Rosaleena MohantyDepartment of Radiology, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA; Department of Neurobiology, Care, Sciences and Society, Karolinska Institute, Sweden.
Veena NairDepartment of Radiology, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.
Margaret ParkerDepartment of Anesthesiology, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.
David KunkelDepartment of Anesthesiology, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.
Cameron RiveraDepartment of Anesthesiology, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.
Cameron CaseyDepartment of Anesthesiology, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.
Henrik ZetterbergDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden; Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK; UK Dementia Research Institute at UCL, London, UK; Hong Kong Center for Neurodegenerative Diseases, Hong Kong, China.
Kaj BlennowDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.
Marko MrkobradaSchulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada.
Philip J DevereauxDepartment of Medicine and Department of Health Research Methods, Evidence & Impact, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada; Perioperative and Surgery Research Group, Population Health Research Institute, Hamilton, ON, Canada; Outcomes Research Consortium, Cleveland, OH, USA.
Robert A PearceDepartment of Anesthesiology, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.
Richard LennertzDepartment of Anesthesiology, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.
Vivek PrabhakaranDepartment of Radiology, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.
Robert D SandersSpecialty of Anaesthetics, Faculty of Medicine and Health, University of Sydney, Sydney, Australia; Department of Anaesthetics, Royal Prince Alfred Hospital, Sydney Local Health District, Camperdown, NSW, Australia; Institute of Academic Surgery, Royal Prince Alfred Hospital, Sydney Local Health District, Camperdown, NSW, Australia. Electronic address: robert.sanders@sydney.edu.au.
University of Wisconsin–Madison · USThe University of Sydney · AUMayo Clinic · USOutcomes Research Consortium · USRoyal Prince Alfred Hospital · AUSahlgrenska University Hospital · SEUniversity of Gothenburg · SEWestern University · CA

Funding

Clarifying the overlapping pathology of delirium and dementiaR01AG063849 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Richard C Lennertz, Robert D Sanders · 2019 to 2026
$5.0M
Stroke Connectome MRI Biomarkers for VCID Risk AssessmentR01NS123378 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI Nagesh Adluru, Veena A Nair · 2022 to 2026
$3.6M
The Juvenile Myoclonic Epilepsy Connectome ProjectR01NS111022 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI STRUCK, AARON F · 2020 to 2024
$3.1M
PET/MR Correlates of Accelerated Aging in Chronic EpilepsyR01NS117568 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI Alan Blair McMillan, Vivek Prabhakaran · 2021 to 2026
$3.0M
Stroke Rehabilitation utilizing BCI technologyR01NS105646 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI PRABHAKARAN, VIVEK · 2018 to 2022
$2.3M
NIA NIH HHS R01 AG063849NINDS NIH HHS R01 NS105646NINDS NIH HHS R01 NS111022NINDS NIH HHS R01 NS117568NINDS NIH HHS R01 NS123378
6 · The paper itself

Abstract

backgroundIschaemic brain infarction can occur without acute neurological symptoms (covert strokes) or with symptoms (overt strokes), both associated with poor health outcomes. We conducted a pilot study of the incidence of preoperative and postoperative (intraoperative or postoperative) covert strokes, and explored the relationship of postoperative ischaemic brain injury to blood levels of neurofilament light, a biomarker of neuronal damage.

methodsWe analysed 101 preoperative (within 2 weeks of surgery) and 58 postoperative research MRIs on postoperative days 2-9 from two prospective cohorts collected at the University of Wisconsin (NCT01980511 and NCT03124303). Participants were aged >65 yr and undergoing non-intracranial, non-carotid surgery.

resultsPreoperative covert stroke was identified in 2/101 participants (2%; Bayesian 95% confidence interval [CI], 0.2-5.4). This rate was statistically different from the postoperative ischaemic brain injury rate of 7/58 (12%, 4.9-21.3%; P=0.01) based on postoperative imaging. However, in a smaller group of participants with paired imaging (n=30), we did not identify the same effect (P=0.67). Patients with postoperative brain injury had elevated peak neurofilament light levels (median [inter-quartile range], 2.34 [2.24-2.64] log

conclusionAlthough limited by a small sample size, these data suggest that preoperative covert stroke occurs more commonly than previously anticipated. Plasma neurofilament light is a potential screening biomarker for postoperative ischaemic brain injury.

Indexed as

Brain InjuriesStrokeAgedBayes TheoremClinical Studies as TopicHumansIntermediate FilamentsPilot ProjectsPostoperative ComplicationsProspective Studiesbrain injurycognitiondeliriumstrokesurgery

Identifiers

PMID36437124
PMCPMC9997085
OpenAlexW4309908046

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.