Evidence map›Paper›PMID 36436931›Full record

ArticleJournal of clinical and experimental hematopathology : JCEH2022

An experience with ibrutinib monotherapy for Richter's syndrome isolated in the central nervous system.

Yuma Nato, Keiki Nagaharu, Kanako Inoue, Kodai Yabu, Akihiko Sawaki, Takuya Shiotani, Yuki Kageyama, Ken Tanaka, Koichi Ohshima, Hiroyuki Miyashita

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical and experimental hematopathology : JCEH, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Yuma NatoDepartment of Hematology, Yokkaichi Municipal Hospital, Yokkaichi, Japan.
Keiki NagaharuDepartment of Hematology, Yokkaichi Municipal Hospital, Yokkaichi, Japan.
Kanako InoueDepartment of Pathology, Kurume University School of Medicine, Kurume, Japan.
Kodai YabuDepartment of Hematology, Yokkaichi Municipal Hospital, Yokkaichi, Japan.
Akihiko SawakiDepartment of Hematology, Yokkaichi Municipal Hospital, Yokkaichi, Japan.
Takuya ShiotaniDepartment of Hematology, Yokkaichi Municipal Hospital, Yokkaichi, Japan.
Yuki KageyamaDepartment of Hematology, Yokkaichi Municipal Hospital, Yokkaichi, Japan.
Ken TanakaDepartment of Pathology, Kurume University School of Medicine, Kurume, Japan.
Koichi OhshimaDepartment of Pathology, Kurume University School of Medicine, Kurume, Japan.
Hiroyuki MiyashitaDepartment of Hematology, Yokkaichi Municipal Hospital, Yokkaichi, Japan.
Yokkaichi Municipal Hospital · JPKurume University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Richter's syndrome (RS) of the central nervous system (CNS) is known to have an extremely poor prognosis. Ibrutinib has been reported to have some activity in patients with RS, despite its poor prognosis. Although ibrutinib crosses the blood-brain barrier, its efficacy in RS patients with CNS involvement remains unknown. Here, we report a case of RS isolated in the CNS that was confirmed to be clonally related to chronic lymphocytic leukemia (CLL) by immunoglobulin heavy chain gene analysis. Although the median survival of patients with RS clonally related to CLL was significantly shorter than that of patients with RS clonally unrelated to CLL, the patient received ibrutinib monotherapy without experiencing any significant adverse events, and the disease remained stable with ibrutinib until 6 weeks later. Following whole-brain radiation therapy (40 Gy in 20 fractions) with dexamethasone, the patient has survived for five months after diagnosis. Thus, ibrutinib may be a safe and effective therapeutic option for patients with RS and CNS involvement.

Indexed as

Brain NeoplasmsLeukemia, Lymphocytic, Chronic, B-CellLymphoma, Large B-Cell, DiffuseAdenineCentral Nervous SystemCranial IrradiationHumansPiperidinesAdenineibrutinibPiperidinesCentral nervous systemIbrutinibImmunoglobulin geneRichter’s syndrome

Identifiers

PMID36436931
PMCPMC9898719
OpenAlexW4310333724

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.