Evidence map›Paper›PMID 36436751›Full record

ArticleInternational journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases2023

SARS-CoV-2 antibodies persist up to 12 months after natural infection in healthy employees working in non-medical contact-intensive professions.

Dymphie Mioch, Leonard Vanbrabant, Johan Reimerink, Sandra Kuiper, Esther Lodder, Wouter van den Bijllaardt, Jan Kluytmans, Michel D Wissing, COco-study group

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Dymphie MiochRegional Public Health Service (GGD) of West-Brabant, Breda, The Netherlands. Electronic address: d.mioch@ggdwestbrabant.nl.
Leonard VanbrabantRegional Public Health Service (GGD) of West-Brabant, Breda, The Netherlands.
Johan ReimerinkNational Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands.
Sandra KuiperRegional Public Health Service (GGD) of West-Brabant, Breda, The Netherlands.
Esther LodderRegional Public Health Service (GGD) of West-Brabant, Breda, The Netherlands.
Wouter van den BijllaardtMicrovida Laboratory for Medical Microbiology, Amphia Hospital, Breda, The Netherlands; Department of Infection Control, Amphia Hospital, Breda, The Netherlands.
Jan KluytmansDepartment of Epidemiology, Julius Centre Research Program Infectious Diseases, University Medical Centre Utrecht, Utrecht, The Netherlands.
Michel D WissingRegional Public Health Service (GGD) of West-Brabant, Breda, The Netherlands.
COco-study group
GGD West-Brabant · NLRadboud University Nijmegen · NLAmphia Ziekenhuis · NLNational Institute for Public Health and the Environment · NLUniversity Medical Center Utrecht · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThis study aimed to evaluate dynamics of antibody levels after exposure to SARS-CoV-2 for 12 months in Dutch non-vaccinated hairdressers and hospitality staff.

methodsIn this prospective cohort study, blood samples were collected every 3 months for 1 year and analyzed using a qualitative total antibody enzyme-linked immunosorbent assay (ELISA) and a quantitative immunoglobulin (Ig)G antibody ELISA. Participants completed questionnaires, providing information on demographics, health, and work. Differences in antibody levels were evaluated using Mann-Whitney U and Wilcoxon signed-rank tests. Beta coefficients (β) and 95% confidence intervals (CIs) were calculated using linear regression.

resultsNinety-five of 497 participants (19.1%) had ≥1 seropositive measurement before their last visit using the qualitative ELISA. Only 2.1% (2/95) seroreverted during follow-up. Of 95 participants, 82 (86.3%) tested IgG seropositive in the quantitative ELISA too. IgG antibody levels significantly decreased in the first months (P <0.01) but remained detectable for up to 12 months in all participants. Older age (β, 10-years increment: 24.6, 95% CI: 5.7-43.5) and higher body mass index (β, 5kg/m² increment: 40.0, 95% CI: 2.9-77.2) were significantly associated with a higher peak of antibody levels.

conclusionIn this cohort, SARS-CoV-2 antibodies persisted for up to 1 year after initial seropositivity, suggesting long-term natural immunity.

Indexed as

COVID-19SARS-CoV-2Antibodies, ViralHumansImmunoglobulin GProspective StudiesAntibodies, ViralImmunoglobulin GCohort studyContact professionCOVID-19 serological testingImmunoglobulin GNatural infectionSARS-CoV-2 antibodies

Identifiers

PMID36436751
PMCPMC9686051
OpenAlexW4310068397

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.