Evidence map›Paper›PMID 36436428›Full record

ArticleJournal of psychiatric research2023

Risk of suicide attempts and self-harm after 1.4 million general medical hospitalizations of men with mental illness.

Rohith Kumar Thiruvalluru, Juliet Beni Edgcomb, John O Brooks, Jyotishman Pathak

Open access · hybridAbstract read
In one paragraph

Article in Journal of psychiatric research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Individual- and population-level associations of mental disorders with intentional self-harm.European psychiatry : the journal of the Association of European Psychiatrists · 2026
    Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Rohith Kumar ThiruvalluruDivision of Health Informatics, Department of Population Health Sciences, Weill Cornell Medicine, 402 E. 67th St., New York, NY, 10065, USA.
Juliet Beni EdgcombUCLA-Semel Institute for Neuroscience and Human Behavior, Department of Psychiatry and Biobehavioral Sciences, University of California at Los Angeles, 760 Westwood Plz, Los Angeles, CA, 90095, USA. Electronic address: jedgcomb@mednet.ucla.edu.
John O BrooksUCLA-Semel Institute for Neuroscience and Human Behavior, Department of Psychiatry and Biobehavioral Sciences, University of California at Los Angeles, 760 Westwood Plz, Los Angeles, CA, 90095, USA.
Jyotishman PathakDivision of Health Informatics, Department of Population Health Sciences, Weill Cornell Medicine, 402 E. 67th St., New York, NY, 10065, USA.
Cornell University · USUniversity of California, Los Angeles · US

Funding

UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
Relief: A Behavioral Intervention for Depression and Chronic Pain for Primary Care PracticesP50MH113838 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI ALEXOPOULOS, GEORGE S · 2017 to 2020
$5.7M
TRAINING THE SCIENCE OF CHILD MENTAL HEALTH TREATMENTT32MH073517 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SUMA JACOB, John C. Piacentini · 2006 to 2026
$5.2M
Linking VA and non-VA data to study the risk of suicide in chronic pain patients.R01MH121907 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI OSLIN, DAVID W., PATHAK, JYOTISHMAN · 2020 to 2024
$3.6M
Using claims data to study the association between Alzheimer's disease and suicidal behaviorsR01MH119177 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI PATHAK, JYOTISHMAN · 2019 to 2022
$3.3M
4/4: Leveraging EHR-linked biobanks for deep phenotyping, polygenic risk score modeling, and outcomes analysis in psychiatric disordersR01MH121922 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI PATHAK, JYOTISHMAN · 2019 to 2023
$2.0M
NCATS NIH HHS UL1 TR001881NIMH NIH HHS P50 MH113838NIMH NIH HHS R01 MH119177NIMH NIH HHS R01 MH121907NIMH NIH HHS R01 MH121922NIMH NIH HHS T32 MH073517
6 · The paper itself

Abstract

backgroundThe short-term risk of suicide after medical hospital discharge is four times higher among men compared with women. As previous work has identified female-specific antecedents of suicide-related behavior after medical hospitalization of women with serious mental illness, we examined predictors among a similar population of men with multimorbidity.

methodsClassification and regression tree (CART) models were developed and validated using electronic health records (EHRs) from 1,423,161 medical (non-psychiatric) hospitalizations of men ≥ 18-years-old with an existing diagnosis of a depressive disorder, bipolar disorder, or chronic psychosis. Hospitalizations occurred between 2009 and 2017. Risk groups were evaluated using an independent testing set. The primary outcome was readmission within one year associated with ICD-9 or -10 code for self-harm or attempt.

resultsThe 1-year readmission rate for intentional self-harm and suicide attempt was 3.9% (55,337/1,423,161 hospitalizations). The classification model discriminated risk with area under the curve (AUC) 0.73 (Confidence Interval [95%CI] 0.68-0.74), accuracy 0.82 (95%CI 0.71-0.83), sensitivity 82.6% (95%CI 81.2-84), and specificity 83.1% (95%CI 81.7-84.5). Strongest predictors were medical comorbidity, prior self-harm, age, and prior hospitalization. Men with greater medical comorbidity burden and prior self-harm were at highest risk (Odds Ratio [OR] 3.10, 95%CI 3.02-3.18), as were men < 62-years-old with few medical comorbidities (OR 1.11 95%CI 1.08-1.13). LIMITATIONS: The study focused on medical hospitalizations for suicide attempt and thus captured only severe attempts resulting in hospitalization.

conclusionsAfter medical hospitalization, men with serious mental illness experienced a high risk of self-harm (1:25 hospitalizations). Risk was particularly elevated among younger patients without prior medical conditions and older patients with medical comorbidity and prior self-harm.

Indexed as

Mental DisordersPsychotic DisordersSelf-Injurious BehaviorAdolescentFemaleHospitalizationHumansMaleMiddle AgedRisk FactorsSuicide, AttemptedMedical hospitalizationMultimorbidityRisk predictionSelf-harmSerious mental illnessSuicide attempt

Identifiers

PMID36436428
PMCPMC10395648
OpenAlexW4308945114

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.