Evidence map›Paper›PMID 36436071›Full record

ArticleEuropean journal of trauma and emergency surgery : official publication of the European Trauma Society2023

Computed tomographic bone mineral density is independently associated with adverse in-hospital outcomes in Dutch level-1 trauma patients.

Tim Kobes, Arthur A R Sweet, Sophie B H Verstegen, R Marijn Houwert, Wouter B Veldhuis, Luke P H Leenen, Pim A de Jong, Mark C P M van Baal

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Article in European journal of trauma and emergency surgery : official publication of the European Trauma Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Tim KobesDepartment of Surgery, University Medical Center Utrecht, P.O. Box 85500, 3508GA, Utrecht, The Netherlands. t.kobes-2@umcutrecht.nl.ORCID http://orcid.org/0000-0003-4618-3714
Arthur A R SweetDepartment of Surgery, University Medical Center Utrecht, P.O. Box 85500, 3508GA, Utrecht, The Netherlands.ORCID http://orcid.org/0000-0003-2061-6403
Sophie B H VerstegenDepartment of Surgery, University Medical Center Utrecht, P.O. Box 85500, 3508GA, Utrecht, The Netherlands.ORCID http://orcid.org/0000-0002-1246-5564
R Marijn HouwertDepartment of Surgery, University Medical Center Utrecht, P.O. Box 85500, 3508GA, Utrecht, The Netherlands.ORCID http://orcid.org/0000-0003-3497-659X
Wouter B VeldhuisDepartment of Radiology, University Medical Center Utrecht, P.O. Box 85500, 3508GA, Utrecht, The Netherlands.ORCID http://orcid.org/0000-0002-9798-6843
Luke P H LeenenDepartment of Surgery, University Medical Center Utrecht, P.O. Box 85500, 3508GA, Utrecht, The Netherlands.ORCID http://orcid.org/0000-0001-8385-1801
Pim A de JongDepartment of Radiology, University Medical Center Utrecht, P.O. Box 85500, 3508GA, Utrecht, The Netherlands.ORCID http://orcid.org/0000-0003-4840-6854
Mark C P M van BaalDepartment of Surgery, University Medical Center Utrecht, P.O. Box 85500, 3508GA, Utrecht, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAging, inactivity, and malnutrition are risk factors for adverse in-hospital outcomes and can manifest in bone loss. Use of bone mineral density (BMD) as an objective marker might improve early identification of patients at risk for complications.

aimTo assess the association of computed tomography (CT) determined BMD values of the first lumbar vertebra with in-hospital complications and outcomes in trauma patients.

methodsAll consecutive hospitalized trauma patients (≥ 16 years) that underwent CT-imaging within 7 days of admission in 2017 were included. Patients with an active infection or antibiotic treatment upon admission, severe neurologic trauma, or an unassessable vertebra were excluded. BMD at the first lumbar vertebra was determined with CT by placing a circular region of interest in homogeneous trabecular bone to obtain mean Hounsfield Units (HU). Regression analyses were performed to assess the association of BMD with in-hospital complications and outcomes.

resultsIn total, 410 patients were included (median age: 49 years [interquartile range 30-64], 68.3% men, mean BMD 159 ± 66 HU). A total of 94 complications, primarily infection-related, were registered in 74 patients. After adjustment for covariates, a decrease of BMD by one standard deviation was significantly associated with increased risk of complications (odds ratio [OR] 1.9, 95% confidence interval [CI] 1.1-3.1), pneumonia (OR 2.2, 95% CI 1.2-4.5), delirium (OR 4.5, 95% CI 1.7-13.5), and intensive care unit (ICU) admission (OR 1.8, 95% CI 1.1-2.9).

conclusionBone mineral density of the first lumbar vertebra is independently associated with in-hospital complications, pneumonia, delirium, and ICU admission. These findings could help identify patients at risk early.

Indexed as

DeliriumOsteoporosisAbsorptiometry, PhotonBone DensityFemaleHospitalsHumansLumbar VertebraeMaleMiddle AgedRetrospective StudiesTomography, X-Ray ComputedBone mineral densityComputed tomographyIn-hospital complicationsOpportunistic screeningTrauma patients

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PMID36436071

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