ArticleJournal of neurology2023
Structural and functional magnetic resonance imaging correlates of fatigue and dual-task performance in progressive multiple sclerosis.
Article in Journal of neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03679468 (Improving Cognition in People With Progressive Multiple Sclerosis), which is not on this map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Improving Cognition in People With Progressive Multiple Sclerosis: A Multi-Arm, Randomized, Blinded, Sham-Controlled Trial of Cognitive Rehabilitation and Aerobic Exercise.
Who cites it
8 citing papers in PubMed, 15 citations in OpenAlex.
- The Role of MRI Lesions in Identifying Secondary Progressive Multiple Sclerosis: A Comprehensive Review.Journal of clinical medicine · 2025Review
- Enhancing Neuroanatomy Teaching with DSI Studio's Fiber Reconstruction Technology.Advances in medical education and practice · 2025Article
- Thalamic nuclei volume partially mediates the effects of aerobic capacity on fatigue in people with multiple sclerosis.Journal of neurology · 2024Article
- Clinical variables influencing the perception of fatigue in people with multiple sclerosis: a cross-sectional study using FSIQ-RMS.BMC neurology · 2024Article
- Dual-Task Performance and Brain Morphologic Characteristics in Parkinson's Disease.Neuro-degenerative diseases · 2024Article
- Evaluating the effects of brain injury, disease and tasks on cognitive fatigue.Scientific reports · 2023Article
- Neuroimaging Technology in Exercise Neurorehabilitation Research in Persons with MS: A Scoping Review.Sensors (Basel, Switzerland) · 2023Article
- Design recommendations for studies that evaluate multiple sclerosis fatigue interventions.Frontiers in psychiatry · 2023Article
Corrections and comments
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Authors and funding
24 authors at 14 institutions in 6 countries.
Funding
Abstract
backgroundFrontal cortico-subcortical dysfunction may contribute to fatigue and dual-task impairment of walking and cognition in progressive multiple sclerosis (PMS). PURPOSE: To explore the associations among fatigue, dual-task performance and structural and functional abnormalities of frontal cortico-subcortical network in PMS.
methodsBrain 3 T structural and functional MRI sequences, Modified Fatigue Impact Scale (MFIS), dual-task motor and cognitive performances were obtained from 57 PMS patients and 10 healthy controls (HC). The associations of thalamic, caudate nucleus and dorsolateral prefrontal cortex (DLPFC) atrophy, microstructural abnormalities of their connections and their resting state effective connectivity (RS-EC) with fatigue and dual-task performance were investigated using random forest.
resultsThirty-seven PMS patients were fatigued (F) (MFIS ≥ 38). Compared to HC, non-fatigued (nF) and F-PMS patients had significantly worse dual-task performance (p ≤ 0.002). Predictors of fatigue (out-of-bag [OOB]-accuracy = 0.754) and its severity (OOB-R
conclusionsIn PMS, structural and functional frontal cortico-subcortical abnormalities contribute to fatigue and worse dual-task performance, with different patterns according to the presence of fatigue.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.