ArticleCommunications biology2022
A cross-cohort replicable and heritable latent dimension linking behaviour to multi-featured brain structure.
Article in Communications biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Multivariate brain-behaviour associations in psychiatric disorders.Translational psychiatry · 2024Pooled it
- Prediction of cognitive performance by demographics, sleep, and brain morphometry: machine learning findings from ENIGMA-Sleep Working Group.Research square · 2026Article
- Multimodal Representation Learning for Parsing Biological Heterogeneity in Psychiatric Neuroimaging.Biological psychiatry · 2026Review
- A pattern-learning algorithm associates copy number variations with brain structure and behavioural variables in an adolescent population cohort.Nature biomedical engineering · 2026Article
- Multivariate associations of motor performance, sleep quality, depressive symptoms, and grey matter volume in younger and mid-to-older adults.Scientific reports · 2026Article
- Dynamic multivariate patterns of brain structure-neuropsychiatric symptom associations in long COVID.Brain communications · 2026Article
- The PAthways to Resilience And Mental health (PARAM) project: protocol for a multi-site developmental cohort in India.BMC psychiatry · 2025Article
- Cardiometabolic health and physical robustness map onto distinct patterns of brain structure and neurotransmitter systems.PLoS biology · 2025Article
- The effect of psychotherapy on the multivariate association between insomnia and depressive symptoms in late-life depression.European psychiatry : the journal of the Association of European Psychiatrists · 2025Article
- The functional overlap between respiration and global signal and its behavioral relevance.Communications biology · 2025Article
- Dataset factors associated with age-related changes in brain structure and function in neurodevelopmental conditions.Human brain mapping · 2024Article
- Heritability of functional gradients in the human subcortico-cortical connectivity.Communications biology · 2024Article
- Lower motor performance is linked with poor sleep quality, depressive symptoms, and grey matter volume alterations.bioRxiv : the preprint server for biology · 2024Article
- The neural correlates of individual differences in numerosity perception: A voxel-based morphometry study.iScience · 2023Article
- The influence of bilingualism on gray matter volume in the course of aging: a longitudinal study.Frontiers in aging neuroscience · 2023Article
Corrections and comments
- Erratum issued
Authors and funding
12 authors.
Funding
Abstract
Identifying associations between interindividual variability in brain structure and behaviour requires large cohorts, multivariate methods, out-of-sample validation and, ideally, out-of-cohort replication. Moreover, the influence of nature vs nurture on brain-behaviour associations should be analysed. We analysed associations between brain structure (grey matter volume, cortical thickness, and surface area) and behaviour (spanning cognition, emotion, and alertness) using regularized canonical correlation analysis and a machine learning framework that tests the generalisability and stability of such associations. The replicability of brain-behaviour associations was assessed in two large, independent cohorts. The load of genetic factors on these associations was analysed with heritability and genetic correlation. We found one heritable and replicable latent dimension linking cognitive-control/executive-functions and positive affect to brain structural variability in areas typically associated with higher cognitive functions, and with areas typically associated with sensorimotor functions. These results revealed a major axis of interindividual behavioural variability linking to a whole-brain structural pattern.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.