ArticleThe American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry2023
A Multi-Dimensional Model of Fatigue in Old Age: Implications for Brain Aging.
Article in The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 7 citations in OpenAlex.
- Autologous adipose-derived mesenchymal stromal cells for chronic traumatic brain injury.Brain : a journal of neurology · 2026Article
- The differential effect of chronological age and brain age on cognitive fatigue: new metrics, new insights.Journal of neurology · 2026Article
- Menopause-related brain fog as a midlife window in women's brain aging: toward ecologically valid measurement and digital phenotyping.Frontiers in human neuroscience · 2026Article
- The role of disease history score in the association between depression history and current ME/CFS among US adults.Frontiers in public health · 2026Article
- Personalized cognitive enhancement for older adults: An aging-friendly closed-loop human-machine interface framework.Ageing research reviews · 2025Review
- Effective engagement in computerized cognitive training for older adults.Ageing research reviews · 2025Review
- Vision-based estimation of fatigue and engagement in cognitive training sessions.Artificial intelligence in medicine · 2024Article
- Association between fatigue, peripheral serotonin, and L-carnitine in hypothyroidism and in chronic fatigue syndrome.Frontiers in endocrinology · 2024Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
As the most reported symptom in old age, fatigue is understudied in terms of both mechanisms and measures. Population heterogeneity and methodological inconsistency makes understanding the relationship between fatigue and brain aging challenging. The present article comprehensively reviews existing conceptual and operational frameworks of fatigue, as well as mechanistic heterogeneities of fatigue that exist in the aging literature. Then, I propose a Multi-Dimensional Model of fatigue to provide theoretical cohesion to the study of fatigue in old age, along with a "fatigue circuit" addressing brain profiles across dimensions of fatigue. The potential relationships between fatigue dimensions, the fatigue circuit, and brain aging are discussed to inform the direction of future research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.