Evidence map›Paper›PMID 36435677›Full record

ArticleTrends in pharmacological sciences2023

Patching holes in the mechanism of opioid tolerance.

Ian B Chronis, Manojkumar A Puthenveedu

Abstract read
In one paragraph

Article in Trends in pharmacological sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Ian B ChronisDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48109, USA. Electronic address: ichronis@umich.edu.
Manojkumar A PuthenveeduDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

Funding

MECHANISMS ENSURING SEQUENCE-DEPENDENT GPCR RECYCLINGR01GM117425 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PUTHENVEEDU, MANOJKUMAR A · 2016 to 2020
$1.5M
Mechanisms Regulating B2AR Sorting to Signaling MicrodomainsF31HL159934 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CHRONIS, IAN BASIL · 2021 to 2023
$118k
NHLBI NIH HHS F31 HL159934NIGMS NIH HHS R01 GM117425
6 · The paper itself

Abstract

Tolerance is a significant obstacle to use of opioids as safe pain relieving drugs, but the cellular processes that result in tolerance have remained elusive. A new study by Maza and colleagues identifies the protein Patched domain-containing 1 (PTCHD1) and its effects on cellular cholesterol as potential targets for preventing opioid tolerance.

Indexed as

Analgesics, OpioidPainDrug ToleranceHumansAnalgesics, OpioidcholesterolGPCRtrafficking

Identifiers

PMID36435677
PMCPMC10320836

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.