Evidence map›Paper›PMID 36435662›Full record

ArticleUltrasound in medicine & biology2023

Preliminary Feasibility of Stress Myocardial Elastography for the Detection of Coronary Artery Disease.

Jad El Harake, Vincent Sayseng, Julien Grondin, Rachel Weber, Andrew J Einstein, Elisa Konofagou

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Ultrasound in medicine & biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Jad El HarakeDepartment of Biomedical Engineering, Columbia University, New York, New York, USA.
Vincent SaysengDepartment of Biomedical Engineering, Columbia University, New York, New York, USA.
Julien GrondinDepartment of Radiology, Columbia University Irving Medical Center and New York-Presbyterian Hospital, New York, New York, USA.
Rachel WeberDepartment of Biomedical Engineering, Columbia University, New York, New York, USA.
Andrew J EinsteinDepartment of Radiology, Columbia University Irving Medical Center and New York-Presbyterian Hospital, New York, New York, USA; Division of Cardiology, Columbia University Irving Medical Center and New York-Presbyterian Hospital, New York, New York, USA; Department of Medicine, Columbia University Irving Medical Center and New York-Presbyterian Hospital, New York, New York, USA.
Elisa KonofagouDepartment of Biomedical Engineering, Columbia University, New York, New York, USA; Department of Radiology, Columbia University Irving Medical Center and New York-Presbyterian Hospital, New York, New York, USA. Electronic address: ek2191@columbia.edu.
Columbia University · USNewYork–Presbyterian Hospital · USColumbia University Irving Medical Center · US

Funding

EARLY DETECTION AND MAPPING OF ISCHEMIA USING MYOCARDIAL ELASTOGRAPHYR01EB006042 · NIBIB · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI KONOFAGOU, ELISA E. · 2006 to 2018
$4.3M
NIBIB NIH HHS R01 EB006042
6 · The paper itself

Abstract

Myocardial elastography (ME) is a cardiac strain imaging technique that has been found capable of detecting a decrease in radial strain caused by ischemia or infarction in patients with coronary artery disease (CAD) as well as in a canine model. Prior studies have focused on rest imaging, but stress testing can reveal functional deficits caused by stenoses that are asymptomatic at rest. Therefore, it has been proposed that stress ME (S-ME) improves the detection of CAD. A novel strain difference (Δε) metric is presented and investigated in a canine model of induced ischemia, as well as in a study in human patients with CAD validated by myocardial perfusion imaging. In the canine model study, flow-limiting stenosis was induced by partial ligation in n = 2 canines, and stenosis was found to consistently reduce Δε in the affected myocardial regions compared with baseline, as well as compared to myocardial regions that are remote to the induced stenosis. In the clinical study, the median Δε was significantly lower (p < 0.05) in infarcted myocardial regions (-6.29%) than in those with normal perfusion (4.62%), with Δε in ischemic regions falling in between (-2.91%). The same trend was observed when considering radial strain during stress and, to a lesser degree, at rest alone. The results indicate that S-ME may be more sensitive to mild cases of CAD that are functionally asymptomatic at rest.

Indexed as

Coronary Artery DiseaseElasticity Imaging TechniquesMyocardial Perfusion ImagingAnimalsConstriction, PathologicCoronary AngiographyDogsFeasibility StudiesHumansIschemiaCardiac strain imagingCoronary artery diseaseElastographyMyocardial perfusion imagingStress test

Identifiers

PMID36435662
PMCPMC9789187
OpenAlexW4309833674

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.