Evidence map›Paper›PMID 36435367›Full record

ArticleMicrobes and infection

Can the triumph of mRNA vaccines against COVID-19 be extended to other viral infections of humans and domesticated animals?

Sharvan Sehrawat, Nikolaus Osterrieder, D Scott Schmid, Barry T Rouse

Abstract read
In one paragraph

Article in Microbes and infection. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sharvan SehrawatDepartment of Biological Sciences, Indian Institute of Science Education and Research Mohali, Sector 81, SAS Nagar Knowledge City, PO Manauli, Mohali 140306, Punjab, India. Electronic address: sharvan@iisermohali.ac.in.
Nikolaus OsterriederInstitut für Virologie, Freie Universität Berlin, Robert-von-Ostertag-Str. 7-13, 14163 Berlin, Germany; Department of Infectious Diseases and Public Health, Jockey Club College of Veterinary Medicine and Life Sciences, City University of Hong Kong, 5F, Block 1B, To Yuen Building, 31 To Yuen Street, Kowloon Tong, Hong Kong. Electronic address: no.34@fu-berlin.de.
D Scott SchmidDepartment of Molecular, Cellular and Developmental Biology, University of Colorado Boulder, Boulder, CO, USA. Electronic address: scott.schmid@live.com.
Barry T RouseCollege of Veterinary Medicine, University of Tennessee Knoxville, TN 37996-0845, USA. Electronic address: btr@utk.edu.

Funding

Mechanisms of Herpetic KeratitisR01EY005093 · NEI · UNIVERSITY OF TENNESSEE KNOXVILLE · PI ROUSE, BARRY T. · 1985 to 2020
$7.8M
Impact of metabolic regulation on viral neuro-virulenceR21AI142862 · NIAID · UNIVERSITY OF TENNESSEE KNOXVILLE · PI ROUSE, BARRY T. · 2019 to 2020
$404k
NEI NIH HHS R01 EY005093NIAID NIH HHS R21 AI142862
6 · The paper itself

Abstract

The unprecedented success of mRNA vaccines in managing the COVID-19 pandemic raises the prospect of applying the mRNA platform to other viral diseases of humans and domesticated animals, which may lead to more efficacious vaccines for some agents. We briefly discuss reasons why mRNA vaccines achieved such success against COVID-19 and indicate what other virus infections and disease conditions might also be ripe for control using mRNA vaccines. We also evaluate situations where mRNA could prove valuable to rebalance the status of immune responsiveness and achieve success as a therapeutic vaccine approach against infections that induce immunoinflammatory lesions.

Indexed as

COVID-19Viral VaccinesVirus DiseasesAnimalsAnimals, DomesticCOVID-19 VaccinesHumansmRNA VaccinesPandemicsRNA, MessengerCOVID-19 VaccinesmRNA VaccinesRNA, MessengerViral VaccinesCOVID-19Human and animalsImmunopathologymRNA vaccinesVirus infections

Identifiers

PMID36435367
PMCPMC9682868

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.