Evidence map›Paper›PMID 36434930›Full record

ArticleNeurobiology of aging2023

Reduced structural connectivity of the medial temporal lobe including the perforant path is associated with aging and verbal memory impairment.

Steven J Granger, Luis Colon-Perez, Myra Saraí Larson, Ilana J Bennett, Michael Phelan, David B Keator, John T Janecek, Mithra T Sathishkumar, Anna P Smith, Liv McMillan and 4 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of aging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Altered NPTX2 dynamics associated with impaired cognitive aging.bioRxiv : the preprint server for biology · 2025
    Article
  2. Quantification of perforant path fibers for early detection of Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Steven J GrangerCenter for the Neurobiology of Learning and Memory, University of California, Irvine, CA; Department of Neurobiology and Behavior, University of California, Irvine, CA.
Luis Colon-PerezCenter for the Neurobiology of Learning and Memory, University of California, Irvine, CA; Department of Neurobiology and Behavior, University of California, Irvine, CA.
Myra Saraí LarsonCenter for the Neurobiology of Learning and Memory, University of California, Irvine, CA; Department of Neurobiology and Behavior, University of California, Irvine, CA.
Ilana J BennettDepartment of Psychology, University of California, Riverside, CA.
Michael PhelanDepartment of Statistics, University of California, Irvine, CA.
David B KeatorDepartment of Psychiatry and Human Behavior, University of California, Irvine, CA.
John T JanecekCenter for the Neurobiology of Learning and Memory, University of California, Irvine, CA; Department of Neurobiology and Behavior, University of California, Irvine, CA.
Mithra T SathishkumarCenter for the Neurobiology of Learning and Memory, University of California, Irvine, CA; Department of Neurobiology and Behavior, University of California, Irvine, CA.
Anna P SmithCenter for the Neurobiology of Learning and Memory, University of California, Irvine, CA; Department of Neurobiology and Behavior, University of California, Irvine, CA.
Liv McMillanCenter for the Neurobiology of Learning and Memory, University of California, Irvine, CA; Department of Neurobiology and Behavior, University of California, Irvine, CA.
Dana GreeniaDepartment of Neurology, University of California, Irvine, CA.
Maria M CorradaDepartment of Neurology, University of California, Irvine, CA.
Claudia H KawasCenter for the Neurobiology of Learning and Memory, University of California, Irvine, CA; Department of Neurobiology and Behavior, University of California, Irvine, CA; Department of Neurology, University of California, Irvine, CA.
Michael A YassaCenter for the Neurobiology of Learning and Memory, University of California, Irvine, CA; Department of Neurobiology and Behavior, University of California, Irvine, CA; Department of Psychiatry and Human Behavior, University of California, Irvine, CA; Department of Neurology, University of California, Irvine, CA. Electronic address: myassa@uci.edu.
University of California, Irvine · USUniversity of California, Riverside · US

Funding

Neuroimaging biomarkers for cognitive decline in elderly with amyloid pathologyR01AG053555 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI Michael A Yassa · 2017 to 2026
$17.0M
Training Program in Learning and MemoryT32MH119049 · NIMH · UNIVERSITY OF CALIFORNIA-IRVINE · PI BRUCE L MCNAUGHTON, Manuella Yassa · 2019 to 2026
$1.4M
Testing the role of tau pathology in disrupting hippocampal CA1 memory function in older adults at risk for Alzheimer’s diseaseR21AG075464 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI YASSA, MICHAEL A · 2022 to 2023
$432k
NIA NIH HHS R01 AG053555NIA NIH HHS R21 AG075464NIMH NIH HHS T32 MH119049
6 · The paper itself

Abstract

The perforant path, the white matter bundle connecting the entorhinal cortex (ERC) with the hippocampal formation deteriorates with age-related cognitive decline. Previous investigations using diffusion-weighted MRI to quantify perforant path integrity in-vivo have been limited due to image resolution or have quantified the perforant path using methods susceptible to partial volume effects such as the tensor model and without consideration of its 3-dimensional morphology. In this investigation, we use quantitative-anisotropy informed tractography derived from ultra-high resolution diffusion imaging (ZOOMit) to investigate structural connectivity of the perforant path and other medial temporal lobe (MTL) pathways in older adults (63 to 98 years old, n = 51). We show that graph density within the MTL declines with age and is associated with lower delayed recall performance. We also show that older age and poorer delayed recall are associated with reduced streamlines connecting the ERC and dentate gyrus of the hippocampus (the putative perforant path). This work suggest that intra-MTL connectivity may new candidate biomarkers for age-related cognitive decline.

Indexed as

Perforant PathwayTemporal LobeAgedAged, 80 and overAgingHippocampusHumansMagnetic Resonance ImagingMemoryMemory DisordersAgingDiffusion weighted MRIHigh resolutionMemoryPerforant path

Identifiers

PMID36434930
PMCPMC10249650
OpenAlexW4308738145

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.