ArticleBioPsychoSocial medicine2022
Utility and optimal cut-off point of the Somatic Symptom Scale-8 for central sensitization syndrome among outpatients with somatic symptoms and related disorders.
Article in BioPsychoSocial medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 7 citations in OpenAlex.
- Psychological and somatosensory correlates of temporomandibular disorder: anxiety, somatosensory amplification, and coping strategies-a biopsychosocial perspective.Journal of oral & facial pain and headache · 2026Article
- Determining the Minimal Clinically Important Difference in Somatic Symptom Scale-8 Score in Patients With Somatic Symptoms and Related Disorders: A Six-Month Follow-Up Study.Alpha psychiatry · 2025Article
- Indeterminate dental pain: clinical characteristics and neurovascular compression; a retrospective case comparative study.Frontiers in pain research (Lausanne, Switzerland) · 2025Article
- Prevalence of central sensitization and somatization in adults with temporomandibular disorders-a prospective observational study.Journal of oral & facial pain and headache · 2024Observational
- Central Sensitization-Related Symptoms and Influencing Factors on Health-Related Quality of Life among Frail Older Adults in Senior Day Care Centers: A Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2024Article
- Exploratory study of cold hypersensitivity in Japanese women: genetic associations and somatic symptom burden.Scientific reports · 2024Article
- Peripheral/central neural microstructural alterations in persistent idiopathic dentoalveolar pain: a case-comparative study.Frontiers in neurologyArticle
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundCentral sensitization syndrome (CSS) involves severe functional symptoms due to central sensitization. for patients with severe somatic symptoms and related disorders (SSRDs), central sensitization may be responsible for their functional symptoms. We hypothesized that screening for CSS in patients with SSRDs would identify those with severe disease. The Somatic Symptom Scale-8 (SSS-8) is a simple tool to assess medical conditions related to SSRDs, but the cut-off point to identify severe cases of comorbid CSS is unknown. This study aimed to determine the optimal cut-off point of SSS-8 for screening the CSS of patients with severe SSRDs.
methodsIn total, 143 patients with SSRDs attending outpatient clinics of a university hospital in Japan were included in the study. The participants were evaluated using the SSS-8 for somatic symptoms, Hospital Anxiety and Depression Scale (HADS) for anxiety and depressive symptoms, Pain Catastrophizing Scale (PCS) for catastrophic thoughts, and Central Sensitization Inventory (CSI-A, B) for CSS. Receiver operating characteristic (ROC) curve analysis was performed using the propensity score. The area under the curve (AUC) was calculated using a propensity score considering PCS, age, sex, HADS, and CSI-B as confounders of SSS-8 and CSS to evaluate differences in diagnostic accuracy between patients with and without SSS-8. The sensitivity and specificity of the ROC analysis were then used to determine the cut-off point for discriminating severe cases of SSS-8.
resultsOf the 143 participants, 126 responded (51 CSS group and 75 non-CSS group), with a valid response rate of 88.1 percent. In the ROC analysis, the propensity score including SSS-8 was statistically more accurate. The optimal cut-off point was 13, with an AUC of 0.88, sensitivity of 84.3 percent, and specificity of 77.3 percent.
conclusionsThe SSS-8 is a useful tool for discriminating severe cases of SSRDs comorbid with CSS.
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