Evidence map›Paper›PMID 36434681›Full record

ArticleLaboratory animal research2022

Time progression and regional expression of brain oxidative stress induced by obstructive jaundice in rats.

Konstantinos Lilimpakis, Aidona Tsepelaki, Electra Kalaitzopoulou, Dimitrios Zisimopoulos, Polyxeni Papadea, Marianna Skipitari, Athina Varemmenou, Apostolos Aggelis, Constantine Vagianos, Constantine Constantoyannis and 1 more

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In one paragraph

Article in Laboratory animal research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
–field-weighted citation impact, top 79% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Konstantinos LilimpakisDepartment of Medicine, Department of Neurosurgery, University of Patras, University Campus, GR26504, Rion, Achaia Patras, Greece. klilimpakis@gmail.com.ORCID http://orcid.org/0000-0003-1665-3009
Aidona TsepelakiDepartment of Medicine, Second Department of Propaedeutic Surgery, National and Kapodistrian University of Athens, 75 Mikras Asias str, 11527, Athens, Goudi, Greece.
Electra KalaitzopoulouDepartment of Biology, University of Patras, University Campus, GR26504, Rion, Achaia Patras, Greece.
Dimitrios ZisimopoulosDepartment of Biology, University of Patras, University Campus, GR26504, Rion, Achaia Patras, Greece.
Polyxeni PapadeaDepartment of Biology, University of Patras, University Campus, GR26504, Rion, Achaia Patras, Greece.
Marianna SkipitariDepartment of Biology, University of Patras, University Campus, GR26504, Rion, Achaia Patras, Greece.
Athina VaremmenouDepartment of Medicine, Department of Neurosurgery, University of Patras, University Campus, GR26504, Rion, Achaia Patras, Greece.
Apostolos AggelisDepartment of Medicine, Second Department of Propaedeutic Surgery, National and Kapodistrian University of Athens, 75 Mikras Asias str, 11527, Athens, Goudi, Greece.
Constantine VagianosDepartment of Medicine, Second Department of Propaedeutic Surgery, National and Kapodistrian University of Athens, 75 Mikras Asias str, 11527, Athens, Goudi, Greece.
Constantine ConstantoyannisDepartment of Medicine, Department of Neurosurgery, University of Patras, University Campus, GR26504, Rion, Achaia Patras, Greece.
Christos D GeorgiouDepartment of Biology, University of Patras, University Campus, GR26504, Rion, Achaia Patras, Greece.
University of Patras · GRNational and Kapodistrian University of Athens · GR

Funding

Andreas Mentzelopoulos Foundation 33720000Hellenic Foundation for Research and Innovation (HFRI) 653
6 · The paper itself

Abstract

backgroundObstructive jaundice induces oxidative changes in the brain parenchyma and plays significant role in clinical manifestations of hepatic encephalopathy. We aim to study the progression of the brain oxidative status over time and the differences of its pattern over the hemispheres, the brainstem and the cerebellum. We use an experimental model in rats and measuring the oxidative stress (OS) specific biomarkers protein malondialdehyde (PrMDA) and protein carbonyls (PrC = O).

resultsHyperbilirubinemia has been confirmed in all study groups as the result of common bile duct obstruction. We confirmed increase in both PrMDA and PrC = O biomarkers levels with different type of changes over time. We also confirmed that the oxidative process develops differently in each of the brain areas in study.

conclusionsThe present study confirms the progressive increase in OS in all brain areas studied using markers indicative of cumulative protein modification.

Indexed as

Lipid peroxidationObstructive jaundiceOxidative stressProtein carbonylsProtein oxidationRhodamine B hydrazide

Identifiers

PMID36434681
PMCPMC9701014
OpenAlexW4310054164

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.