ArticleNeuroinformatics2023
Federated Analysis in COINSTAC Reveals Functional Network Connectivity and Spectral Links to Smoking and Alcohol Consumption in Nearly 2,000 Adolescent Brains.
Abstract read
In one paragraph
Article in Neuroinformatics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 17% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.
- Relating Functional Connectivity and Alcohol Use Disorder: A Systematic Review and Derivation of Relevance Maps for Regions and Connections.Human brain mapping · 2025Pooled it
- Open neuroinformatics infrastructure ecosystem for federated multisite studies.bioRxiv : the preprint server for biology · 2026Article
- Functional Networks of Reward and Punishment Processing and Their Molecular Profiles Predicting the Severity of Young Adult Drinking.Brain sciences · 2024Article
- Aberrant resting-state functional connectivity associated with childhood trauma among juvenile offenders.NeuroImage. Clinical · 2023Article
- Aging brain shows joint declines in brain within-network connectivity and between-network connectivity: a large-sample study (Frontiers in aging neuroscience · 2023Article
- Enhancing collaborative neuroimaging research: introducing COINSTAC Vaults for federated analysis and reproducibility.Frontiers in neuroinformatics · 2023Article
- Psychopathic traits and altered resting-state functional connectivity in incarcerated adolescent girls.Frontiers in neuroimaging · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
55 authors at 20 institutions in 8 countries.
Harshvardhan Gazula *Martinos Center for Biomedical Imaging, MGH and Harvard Medical School, Boston, USA. hvgazula@umich.edu.ORCID 0000-0001-9318-8871
Kelly Rootes-Murdy *Tri-institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State University, Georgia Institute of Technology, Emory University, Atlanta, GA, USA.
Bharath HollaDepartment of Psychiatry, National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru, India. hollabharath@gmail.com.
Sunitha BasodiTri-institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State University, Georgia Institute of Technology, Emory University, Atlanta, GA, USA.
Zuo ZhangCentre for Population Neuroscience and Precision Medicine (PONS), Institute of Psychiatry, Psychology & Neuroscience, SGDP Centre, King's College London, London, SE5 8AF, United Kingdom.
Eric VernerTri-institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State University, Georgia Institute of Technology, Emory University, Atlanta, GA, USA.
Ross KellyTri-institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State University, Georgia Institute of Technology, Emory University, Atlanta, GA, USA.
Pratima MurthyDepartment of Psychiatry, National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru, India.
Amit ChakrabartiICMR-Center on Non-communicable Diseases, Kolkata, India.
Debasish BasuDepartment of Psychiatry, Postgraduate Institute of Medical Education & Research, Chandigarh, India.
Subodh Bhagyalakshmi NanjayyaDepartment of Psychiatry, Postgraduate Institute of Medical Education & Research, Chandigarh, India.
Rajkumar Lenin SinghDepartment of Psychiatry, Regional Institute of Medical Sciences, Imphal, Manipur, India.
Roshan Lourembam SinghDepartment of Psychology, Regional Institute of Medical Sciences, Imphal, Manipur, India.
Kartik KalyanramRural Health Centre, Rishi Valley, Andhra Pradesh, India.
Kamakshi KartikRural Health Centre, Rishi Valley, Andhra Pradesh, India.
Kumaran KalyanaramanEpidemiology Research Unit, CSI Holdsworth Memorial Hospital, Mysore, India.
Krishnaveni GhattuEpidemiology Research Unit, CSI Holdsworth Memorial Hospital, Mysore, India.
Rebecca KuriyanDivision of Nutrition, St John's Research Institute, Bengaluru, India.
Sunita Simon KurpadDepartment of Psychiatry & Department of Medical Ethics, St. John's Medical College & Hospital, Bangalore, India.
Gareth J BarkerDepartment of Neuroimaging, Institute of Psychology, Psychiatry & Neuroscience, King's College London, London, UK.
Rose Dawn BharathDepartment of Neuroimaging and Interventional Radiology, NIMHANS, Bengaluru, India.
Sylvane DesrivieresCentre for Population Neuroscience and Precision Medicine (PONS), Institute of Psychiatry, Psychology & Neuroscience, SGDP Centre, King's College London, London, SE5 8AF, United Kingdom.
Meera PurushottamMolecular Genetics Laboratory, NIMHANS, Bengaluru, India.
Dimitri Papadopoulos OrfanosNeuroSpin, CEA, Université Paris-Saclay, Paris, France.
Eesha SharmaDepartment of Child & Adolescent Psychiatry, NIMHANS, Bengaluru, India.
Matthew HickmanBristol Medical School, University of Bristol, Bristol, UK.
Mireille ToledanoMRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.
Nilakshi VaidyaCentre for Addiction Medicine, NIMHANS, Bengaluru, India.
Tobias BanaschewskiDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, Mannheim, 68159, Germany.
Arun L W BokdeDiscipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland.
Herta FlorInstitute of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, Mannheim, Germany.
Antoine GrigisNeuroSpin, CEA, Université Paris-Saclay, Paris, France.
Hugh GaravanDepartments of Psychiatry and Psychology, University of Vermont, Burlington, Vermont, 05405, USA.
Penny GowlandSir Peter Mansfield Imaging Centre School of Physics and Astronomy, University of Nottingham, University Park, Nottingham, United Kingdom.
Andreas HeinzDepartment of Psychiatry and Psychotherapy CCM, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Rüdiger BrühlPhysikalisch-Technische Bundesanstalt (PTB), Braunschweig and Berlin, Berlin, Germany.
Jean-Luc MartinotInstitut National de la Santé et de la Recherche Médicale, INSERM U A10 "Trajectoires développementales en psychiatrie"; Université Paris-Saclay, Ecole Normale supérieure Paris-Saclay, CNRS, Centre Borelli;, Gif-sur-Yvette, France.
Marie-Laure Paillére MartinotInstitut National de la Santé et de la Recherche Médicale, INSERM U A10 "Trajectoires développementales en psychiatrie"; Université Paris-Saclay, Ecole Normale supérieure Paris-Saclay, CNRS, Centre Borelli;, Gif-sur-Yvette, France.
Eric ArtigesInstitut National de la Santé et de la Recherche Médicale, INSERM U A10 "Trajectoires développementales en psychiatrie"; Université Paris-Saclay, Ecole Normale supérieure Paris-Saclay, CNRS, Centre Borelli;, Gif-sur-Yvette, France.
Frauke NeesCentre for Population Neuroscience and Precision Medicine (PONS), Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Berlin, Germany.
Tomás PausDepartment of Psychiatry, Faculty of Medicine and Centre Hospitalier Universitaire Sainte-Justine, University of Montreal, Montreal, Quebec, Canada.
Luise PoustkaDepartment of Child and Adolescent Psychiatry and Psychotherapy, University Medical Centre Göttingen, von-Siebold-Str. 5, Göttingen, 37075, Germany.
Juliane H FröhnerDepartment of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, Germany.
Lauren RobinsonDepartment of Psychological Medicine, Section for Eating Disorders, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, SE5 8AF, UK.
Michael N SmolkaDepartment of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, Germany.
Henrik WalterDepartment of Psychiatry and Psychotherapy CCM, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Jeanne WintererDepartment of Psychiatry and Psychotherapy CCM, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Robert WhelanSchool of Psychology and Global Brain Health Institute, Trinity College Dublin, Dublin, Ireland.
IMAGEN Consortium
Jessica A TurnerTri-institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State University, Georgia Institute of Technology, Emory University, Atlanta, GA, USA.
Anand D SarwateDepartment of Electrical and Computer Engineering, Rutgers, The State University of New Jersey, Piscataway, NJ, USA.
Sergey M PlisTri-institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State University, Georgia Institute of Technology, Emory University, Atlanta, GA, USA.
Vivek BenegalDepartment of Psychiatry, National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru, India.
Gunter SchumannCentre for Population Neuroscience and Precision Medicine (PONS), Institute of Psychiatry, Psychology & Neuroscience, SGDP Centre, King's College London, London, SE5 8AF, United Kingdom.
Vince D CalhounTri-institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State University, Georgia Institute of Technology, Emory University, Atlanta, GA, USA.
Georgia Institute of Technology · USNational Institute of Mental Health and Neurosciences · INKing's College London · GBCentre National de la Recherche Scientifique · FRHumboldt-Universität zu Berlin · DECommissariat à l'Énergie Atomique et aux Énergies Alternatives · FRCSI Holdsworth Memorial Hospital · INHeidelberg University · DEPost Graduate Institute of Medical Education and Research · INRegional Institute of Medical Sciences · INTechnische Universität Dresden · DETrinity College Dublin · IEHarvard University · USMRC Centre for Environment and HealthPhysikalisch-Technische Bundesanstalt · DERutgers, The State University of New Jersey · USSt.John's Medical College Hospital · INUniversity of Bristol · GBUniversity of Göttingen · DEUniversity of Mannheim · DE
Funding
Training U54EB020403 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2014 to 2018
$10.1MCOINSTAC: Decentralized, Scalable Analysis of Loosely Coupled DataR01DA040487 · NIDA · THE MIND RESEARCH NETWORK · PI CALHOUN, VINCE D, PLIS, SERGEY · 2015 to 2024
$7.1MENIGMA-COINSTAC-APOE2 Functional and structural connectome protective mechanisms for Alzheimer’s disease and mood disorders: Request for supplemental funds for NIH R01:1R01MH121246R01MH121246 · NIMH · OHIO STATE UNIVERSITY · PI CALHOUN, VINCE D, TURNER, JESS · 2019 to 2023
$5.0MA decentralized macro and micro gene-by-environment interaction analysis of substance use behavior and its brain biomarkers R01DA049238 · NIDA · GEORGIA STATE UNIVERSITY · PI CALHOUN, VINCE D, LIU, JINGYU · 2019 to 2023
$2.9MENIGMA World Aging CenterR56AG058854 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2018 to 2018
$683kDepartment of Health PR-ST-0416-10001Medical Research Council MR/L022206/1Medical Research Council MR/N000390/1Medical Research Council MR/N00616X/1Medical Research Council MR/R00465X/1Medical Research Council MR/S019669/1Medical Research Council MR/S020306/1Medical Research Council MR/W002418/1MRF_ MRF-058-0004-RG-DESRIMRF_ MRF-058-0009-RG-DESR-C0759NIA NIH HHS R56 AG058854NIBIB NIH HHS U54 EB020403NIDA NIH HHS R01 DA040487NIDA NIH HHS R01 DA049238NIMH NIH HHS R01 MH121246
Abstract
With the growth of decentralized/federated analysis approaches in neuroimaging, the opportunities to study brain disorders using data from multiple sites has grown multi-fold. One such initiative is the Neuromark, a fully automated spatially constrained independent component analysis (ICA) that is used to link brain network abnormalities among different datasets, studies, and disorders while leveraging subject-specific networks. In this study, we implement the neuromark pipeline in COINSTAC, an open-source neuroimaging framework for collaborative/decentralized analysis. Decentralized exploratory analysis of nearly 2000 resting-state functional magnetic resonance imaging datasets collected at different sites across two cohorts and co-located in different countries was performed to study the resting brain functional network connectivity changes in adolescents who smoke and consume alcohol. Results showed hypoconnectivity across the majority of networks including sensory, default mode, and subcortical domains, more for alcohol than smoking, and decreased low frequency power. These findings suggest that global reduced synchronization is associated with both tobacco and alcohol use. This proof-of-concept work demonstrates the utility and incentives associated with large-scale decentralized collaborations spanning multiple sites.
Indexed as
BrainMagnetic Resonance ImagingAdolescentAlcohol DrinkingBrain MappingEthanolHumansNeural PathwaysSmokingEthanolAdolescent healthCOINSTACCVEDADecentralized analysisIMAGENNeuromark
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.