Evidence map›Paper›PMID 36434036›Full record

ArticleScientific reports2022

Visualisation of lenticulostriate arteries using contrast-enhanced time-of-flight magnetic resonance angiography at 7 Tesla.

Christopher N Osuafor, Catarina Rua, Andrew D Mackinnon, Marco Egle, Philip Benjamin, Daniel J Tozer, Christopher T Rodgers, Hugh S Markus

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Christopher N OsuaforStroke Research Group, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK. co400@cam.ac.uk.
Catarina RuaDepartment of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
Andrew D MackinnonAtkinson Morley Regional Neuroscience Centre, St George's University Hospitals NHS Foundation Trust, London, UK.
Marco EgleStroke Research Group, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
Philip BenjaminAtkinson Morley Regional Neuroscience Centre, St George's University Hospitals NHS Foundation Trust, London, UK.
Daniel J TozerStroke Research Group, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
Christopher T RodgersWolfson Brain Imaging Centre, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
Hugh S MarkusStroke Research Group, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
University of Cambridge · GBSt George’s University Hospitals NHS Foundation Trust · GB

Funding

British Heart Foundation PG/19/74/34670British Heart Foundation RE/18/1/34212NIHR Cambridge Biomedical Research Centre BRC-1215-20014
6 · The paper itself

Abstract

7 Tesla-field-strength (7 T) Magnetic Resonance Imaging allows the small perforating arteries in the brain to be visualised, and this modality may allow visualisation of the arterial pathology in cerebral small vessel disease. Most studies have used standard Time-of-Flight (ToF) Magnetic Resonance Angiography (MRA). Whether the use of contrast enhancement improves perforating artery visualisation at 7 T remains unclear. In a prospective study, we compared standard ToF MRA with contrast-enhanced (CE) ToF MRA at 7 T for the visualisation of the lenticulostriate arteries (LSAs). Ten patients with symptomatic lacunar stroke were recruited (mean age, SD, 64 ± 9.9 years). Visualisation was assessed using a visual rating scale administered by two independent expert readers and length of the LSAs visible. Visualisation of the LSAs was improved with CE ToF MRA. The mean Visibility and Sharpness Score was higher for CE ToF MRA over standard ToF MRA (2.55 ± 0.64 vs. 1.75 ± 0.68; P = 0.0008). The mean length of LSA visualised was significantly longer with CE ToF MRA compared to standard ToF MRA (24.4 ± 4.5 vs. 21.9 ± 4.0 mm; P = 0.01). CE ToF MRA offers improved visualisation of the LSAs over standard ToF MRA. The addition of contrast may improve the ability to visualise cerebral small vessel disease arterial pathology.

Indexed as

Cerebral Small Vessel DiseasesMagnetic Resonance AngiographyAgedHumansMagnetic Resonance ImagingMiddle AgedMiddle Cerebral ArteryProspective Studies

Identifiers

PMID36434036
PMCPMC9700841
OpenAlexW4310057284

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.