Evidence map›Paper›PMID 36434017›Full record

ArticleNPJ Parkinson's disease2022

Detecting Parkinson's disease and its cognitive phenotypes via automated semantic analyses of action stories.

Adolfo M García, Daniel Escobar-Grisales, Juan Camilo Vásquez Correa, Yamile Bocanegra, Leonardo Moreno, Jairo Carmona, Juan Rafael Orozco-Arroyave

Open access · goldAbstract read
In one paragraph

Article in NPJ Parkinson's disease, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.

  1. Pooled it
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  4. The include network: Advancing cross-linguistic equity in brain health research.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
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  8. Cognitive Phenotyping of Parkinson's Disease Patients Via Digital Analysis of Spoken Word Properties.Movement disorders : official journal of the Movement Disorder Society · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 6 countries.

Adolfo M García *Global Brain Health Institute, University of California, San Francisco, USA. adolfo.garcia@gbhi.org.ORCID http://orcid.org/0000-0002-6936-0114
Daniel Escobar-Grisales *GITA Lab, Faculty of Engineering, Universidad de Antioquia UdeA, Medellín, Colombia.ORCID http://orcid.org/0000-0002-3257-0134
Juan Camilo Vásquez CorreaFundación Vicomtech, Basque Research and Technology Alliance (BRTA), Donostia, San Sebastián, Spain.
Yamile BocanegraGrupo de Neurociencias de Antioquia, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia.
Leonardo MorenoSección de Neurología, Hospital Pablo Tobón Uribe, Medellín, Colombia.
Jairo CarmonaGrupo Neuropsicología y Conducta (GRUNECO), Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia.
Juan Rafael Orozco-ArroyaveGITA Lab, Faculty of Engineering, Universidad de Antioquia UdeA, Medellín, Colombia. rafael.orozco@udea.edu.co.ORCID http://orcid.org/0000-0002-8507-0782
Universidad de Antioquia · COFriedrich-Alexander-Universität Erlangen-Nürnberg · DEHospital Pablo Tobon Uribe · COUniversidad de Santiago de Chile · CLVicomtech · ES

Funding

Alzheimer's Association GBHI ALZ UK-22-865742Universidad de Antioquia (University of Antioquia) CODI PRG2020-34068
6 · The paper itself

Abstract

Action-concept outcomes are useful targets to identify Parkinson's disease (PD) patients and differentiate between those with and without mild cognitive impairment (PD-MCI, PD-nMCI). Yet, most approaches employ burdensome examiner-dependent tasks, limiting their utility. We introduce a framework capturing action-concept markers automatically in natural speech. Patients from both subgroups and controls retold an action-laden and a non-action-laden text (AT, nAT). In each retelling, we weighed action and non-action concepts through our automated Proximity-to-Reference-Semantic-Field (P-RSF) metric, for analysis via ANCOVAs (controlling for cognitive dysfunction) and support vector machines. Patients were differentiated from controls based on AT (but not nAT) P-RSF scores. The same occurred in PD-nMCI patients. Conversely, PD-MCI patients exhibited reduced P-RSF scores for both texts. Direct discrimination between patient subgroups was not systematic, but it yielded best outcomes via AT scores. Our approach outperformed classifiers based on corpus-derived embeddings. This framework opens scalable avenues to support PD diagnosis and phenotyping.

Identifiers

PMID36434017
PMCPMC9700793
OpenAlexW4310062613

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.