Evidence map›Paper›PMID 36433985›Full record

ArticleScientific data2022

MaHPIC malaria systems biology data from Plasmodium cynomolgi sporozoite longitudinal infections in macaques.

Jeremy D DeBarry, Mustafa V Nural, Suman B Pakala, Vishal Nayak, Susanne Warrenfeltz, Jay Humphrey, Stacey A Lapp, Monica Cabrera-Mora, Cristiana F A Brito, Jianlin Jiang and 36 more

Open access · goldAbstract readDataset
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific data, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Malaria disrupts the rhesus macaque gut microbiome.Frontiers in cellular and infection microbiology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

46 authors at 8 institutions in 2 countries.

Jeremy D DeBarryInstitute of Bioinformatics, University of Georgia, Athens, GA, 30602, USA.ORCID 0000-0001-5718-2675
Mustafa V NuralInstitute of Bioinformatics, University of Georgia, Athens, GA, 30602, USA.ORCID 0000-0002-1871-076X
Suman B PakalaInstitute of Bioinformatics, University of Georgia, Athens, GA, 30602, USA.ORCID 0000-0001-5156-0823
Vishal NayakInstitute of Bioinformatics, University of Georgia, Athens, GA, 30602, USA.
Susanne WarrenfeltzCenter for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA, 30602, USA.ORCID 0000-0002-9789-8878
Jay HumphreyInstitute of Bioinformatics, University of Georgia, Athens, GA, 30602, USA.
Stacey A LappEmory Vaccine Center, Yerkes/Emory National Primate Research Center, Emory University, Atlanta, GA, 30329, USA.
Monica Cabrera-MoraEmory Vaccine Center, Yerkes/Emory National Primate Research Center, Emory University, Atlanta, GA, 30329, USA.
Cristiana F A BritoEmory Vaccine Center, Yerkes/Emory National Primate Research Center, Emory University, Atlanta, GA, 30329, USA.ORCID 0000-0002-8888-5477
Jianlin JiangEmory Vaccine Center, Yerkes/Emory National Primate Research Center, Emory University, Atlanta, GA, 30329, USA.
Celia L SaneyEmory Vaccine Center, Yerkes/Emory National Primate Research Center, Emory University, Atlanta, GA, 30329, USA.
Allison HankusEmory Vaccine Center, Yerkes/Emory National Primate Research Center, Emory University, Atlanta, GA, 30329, USA.
Hannah M StealeyInstitute of Bioinformatics, University of Georgia, Athens, GA, 30602, USA.ORCID 0000-0002-1116-2596
Megan B DeBarryInstitute of Bioinformatics, University of Georgia, Athens, GA, 30602, USA.
Nicolas LackmanInstitute of Bioinformatics, University of Georgia, Athens, GA, 30602, USA.
Noah LegallInstitute of Bioinformatics, University of Georgia, Athens, GA, 30602, USA.
Kevin LeeCenter for Integrative Genomics, School of Biology, Georgia Institute of Technology, Atlanta, GA, 30332, USA.
Yan TangSchool of Chemical & Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA, 30332, USA.
Anuj GuptaThe Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, 30332, USA.ORCID 0000-0001-7887-3897
Elizabeth D TrippeInstitute of Bioinformatics, University of Georgia, Athens, GA, 30602, USA.ORCID 0000-0001-7290-2095
Robert R BridgerComplex Carbohydrate Research Center, Department of Biochemistry, University of Georgia, Athens, GA, 30602, USA.
Daniel Brent WeatherlyComplex Carbohydrate Research Center, Department of Biochemistry, University of Georgia, Athens, GA, 30602, USA.
Mariko S PetersonEmory Vaccine Center, Yerkes/Emory National Primate Research Center, Emory University, Atlanta, GA, 30329, USA.
Xuntian JiangDivision of Endocrinology, Metabolism & Lipid Research, Washington University School of Medicine, St. Louis, MO, 63110, USA.ORCID 0000-0001-9048-7294
ViLinh TranDivision of Pulmonary, Allergy, Critical Care, & Sleep Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, GA, 30322, USA.
Karan UppalDivision of Pulmonary, Allergy, Critical Care, & Sleep Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, GA, 30322, USA.
Luis L FonsecaThe Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, 30332, USA.ORCID 0000-0002-7902-742X
Chester J JoynerEmory Vaccine Center, Yerkes/Emory National Primate Research Center, Emory University, Atlanta, GA, 30329, USA.
Ebru KarpuzogluEmory Vaccine Center, Yerkes/Emory National Primate Research Center, Emory University, Atlanta, GA, 30329, USA.
Regina J CordyEmory Vaccine Center, Yerkes/Emory National Primate Research Center, Emory University, Atlanta, GA, 30329, USA.ORCID 0000-0002-5369-0215
Esmeralda V S MeyerEmory Vaccine Center, Yerkes/Emory National Primate Research Center, Emory University, Atlanta, GA, 30329, USA.
Lance L WellsComplex Carbohydrate Research Center, Department of Biochemistry, University of Georgia, Athens, GA, 30602, USA.ORCID 0000-0003-4956-5363
Daniel S OryDivision of Endocrinology, Metabolism & Lipid Research, Washington University School of Medicine, St. Louis, MO, 63110, USA.
F Eun-Hyung LeeDivision of Pulmonary, Allergy, Critical Care, & Sleep Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, GA, 30322, USA.ORCID 0000-0002-6133-5942
Rabindra TirouvanziamDepartment of Pediatrics, Emory University School of Medicine, Atlanta, GA, 30322, USA.
Juan B GutiérrezInstitute of Bioinformatics, University of Georgia, Athens, GA, 30602, USA.ORCID 0000-0002-0627-5035
Chris IbegbuEmory Vaccine Center, Yerkes/Emory National Primate Research Center, Emory University, Atlanta, GA, 30329, USA.
Tracey J LambDepartment of Pediatrics, Emory University School of Medicine, Atlanta, GA, 30322, USA.
Jan PohlBiotechnology Core Facility Branch, Centers for Disease Control and Prevention, Atlanta, GA, 30333, USA.
Sarah T PruettYerkes/Emory National Primate Research Center, Emory University, Atlanta, GA, 30329, USA.ORCID 0000-0003-1324-4787
Dean P JonesDivision of Pulmonary, Allergy, Critical Care, & Sleep Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, GA, 30322, USA.ORCID 0000-0002-2090-0677
Mark P StyczynskiSchool of Chemical & Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA, 30332, USA.ORCID 0000-0002-1479-6658
Eberhard O VoitThe Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, 30332, USA.ORCID 0000-0003-1378-3043
Alberto MorenoDivision of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA, 30322, USA.ORCID 0000-0002-3031-7194
Mary R GalinskiEmory Vaccine Center, Yerkes/Emory National Primate Research Center, Emory University, Atlanta, GA, 30329, USA.
Jessica C KissingerInstitute of Bioinformatics, University of Georgia, Athens, GA, 30602, USA. jkissing@uga.edu.ORCID 0000-0002-6413-1101
Emory University · USUniversity of Georgia · USGeorgia Institute of Technology · USWashington University in St. Louis · USBrigham and Women's Hospital · USCARE USA · USCenters for Disease Control and Prevention · USUnited States Food and Drug Administration · US

Funding

Yerkes National Primate Research Center Role of type-I IFN in regulating COVID-19 induced inflammation and pathogenesisP51OD011132 · OD · EMORY UNIVERSITY · PI Joon Sup Lee · 2012 to 2026
$167.0M
Regulation of Pathogenic Plasma Cells in Human SLEP01AI125180 · NIAID · EMORY UNIVERSITY · PI Ignacio E. Sanz · 2016 to 2026
$28.2M
WU P&FP30DK020579 · NIDDK · WASHINGTON UNIVERSITY · PI Clay F. Semenkovich · 2013 to 2026
$27.1M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM008169 · NIGMS · EMORY UNIVERSITY · PI GROSS, ROBERT E · 1987 to 2021
$20.3M
Virus-induced Cell Fate Decisions in Anti-Viral ImmunityU19AI109962 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI RANDALL, TROY D · 2014 to 2018
$11.6M
Role of B Cells in Synovial Inflammation & LN Remodeling in RA ArthritisP01AI078907 · NIAID · UNIVERSITY OF ROCHESTER · PI ANOLIK, JENNIFER HOWITT · 2010 to 2014
$10.8M
Medical Scientist Training ProgramT32GM142617 · NIGMS · EMORY UNIVERSITY · PI Jason Yustein · 2022 to 2026
$7.0M
Understanding Survival of Human Bone Marrow Long-Lived Plasma CellsR01AI121252 · NIAID · EMORY UNIVERSITY · PI LEE, FRANCES EUN-HYUNG · 2016 to 2020
$2.7M
Suppression of anti-malarial humoral immune responses by gamaherpesvirusesR01AI123425 · NIAID · UNIVERSITY OF UTAH · PI LAMB, TRACEY JANE · 2017 to 2021
$1.9M
CLC NIH HHS C0000008NIAID NIH HHS HHSN272201200031CNIAID NIH HHS P01 AI078907NIAID NIH HHS P01 AI125180NIAID NIH HHS R01 AI121252NIAID NIH HHS R01 AI123425NIAID NIH HHS U19 AI109962NIDDK NIH HHS P30 DK020579NIGMS NIH HHS T32 GM008169NIGMS NIH HHS T32 GM142617NIH HHS P51 OD011132
6 · The paper itself

Abstract

Plasmodium cynomolgi causes zoonotic malarial infections in Southeast Asia and this parasite species is important as a model for Plasmodium vivax and Plasmodium ovale. Each of these species produces hypnozoites in the liver, which can cause relapsing infections in the blood. Here we present methods and data generated from iterative longitudinal systems biology infection experiments designed and performed by the Malaria Host-Pathogen Interaction Center (MaHPIC) to delve deeper into the biology, pathogenesis, and immune responses of P. cynomolgi in the Macaca mulatta host. Infections were initiated by sporozoite inoculation. Blood and bone marrow samples were collected at defined timepoints for biological and computational experiments and integrative analyses revolving around primary illness, relapse illness, and subsequent disease and immune response patterns. Parasitological, clinical, haematological, immune response, and -omic datasets (transcriptomics, proteomics, metabolomics, and lipidomics) including metadata and computational results have been deposited in public repositories. The scope and depth of these datasets are unprecedented in studies of malaria, and they are projected to be a F.A.I.R., reliable data resource for decades.

Indexed as

MalariaPlasmodium cynomolgiAnimalsHost-Pathogen InteractionsMacaca mulattaSporozoitesSystems BiologyZoonoses

Identifiers

PMID36433985
PMCPMC9700667
OpenAlexW4310060529

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.