Evidence map›Paper›PMID 36433662›Full record

Trial reportActa physiologica (Oxford, England)2023

The effect of specific bioactive collagen peptides on function and muscle remodeling during human resistance training.

Thomas G Balshaw, Mark P Funnell, Emmet McDermott, Thomas M Maden-Wilkinson, Sean Abela, Btool Quteishat, Max Edsey, Lewis J James, Jonathan P Folland

Erratum issuedOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Acta physiologica (Oxford, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 17 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 3 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 3 syntheses or guidelines pooled it, 25 citations in OpenAlex.

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  14. Muscle and tendon morphology of a world strongman and deadlift champion.Journal of applied physiology (Bethesda, Md. : 1985) · 2024
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  15. Sex differences in muscle morphology between male and female sprinters.Journal of applied physiology (Bethesda, Md. : 1985) · 2024
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Thomas G BalshawSchool of Sport, Exercise, and Health Sciences, Loughborough University, Leicestershire, UK.ORCID 0000-0001-6935-8228
Mark P FunnellSchool of Sport, Exercise, and Health Sciences, Loughborough University, Leicestershire, UK.
Emmet McDermottSchool of Sport, Exercise, and Health Sciences, Loughborough University, Leicestershire, UK.
Thomas M Maden-WilkinsonAcademy of Sport and Physical Activity, Faculty of Health and Wellbeing, Collegiate Campus, Sheffield Hallam University, Sheffield, UK.ORCID 0000-0002-6191-045X
Sean AbelaSchool of Sport, Exercise, and Health Sciences, Loughborough University, Leicestershire, UK.
Btool QuteishatSchool of Sport, Exercise, and Health Sciences, Loughborough University, Leicestershire, UK.
Max EdseySchool of Sport, Exercise, and Health Sciences, Loughborough University, Leicestershire, UK.
Lewis J JamesSchool of Sport, Exercise, and Health Sciences, Loughborough University, Leicestershire, UK.
Jonathan P FollandSchool of Sport, Exercise, and Health Sciences, Loughborough University, Leicestershire, UK.
Loughborough University · GBSheffield Hallam University · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimBioactive collagen peptides (CP) have been suggested to augment the functional, structural (size and architecture), and contractile adaptations of skeletal muscle to resistance training (RT), but with limited evidence. This study aimed to determine if CP vs. placebo (PLA) supplementation enhanced the functional and underpinning structural, and contractile adaptations after 15 weeks of lower body RT.

methodsYoung healthy males were randomized to consume either 15 g of CP (n = 19) or PLA (n = 20) once every day during a standardized program of progressive knee extensor, knee flexor, and hip extensor RT 3 times/wk. Measurements pre- and post-RT included: knee extensor and flexor isometric strength; quadriceps, hamstrings, and gluteus maximus volume with MRI; evoked twitch contractions, 1RM lifting strength, and architecture (with ultrasound) of the quadriceps.

resultsPercentage changes in maximum strength (isometric or 1RM) did not differ between-groups (0.684 ≤ p ≤ 0.929). Increases in muscle volume were greater (quadriceps 15.2% vs. 10.3%; vastus medialis (VM) 15.6% vs. 9.7%; total muscle volume 15.7% vs. 11.4%; [all] p ≤ 0.032) or tended to be greater (hamstring 16.5% vs. 12.8%; gluteus maximus 16.6% vs. 12.9%; 0.089 ≤ p ≤ 0.091) for CP vs. PLA. There were also greater increases in twitch peak torque (22.3% vs. 12.3%; p = 0.038) and angle of pennation of the VM (16.8% vs. 5.8%, p = 0.046), but not other muscles, for CP vs. PLA.

conclusionsCP supplementation produced a cluster of consistent effects indicating greater skeletal muscle remodeling with RT compared to PLA. Notably, CP supplementation amplified the quadriceps and total muscle volume increases induced by RT.

Indexed as

Resistance TrainingHumansIsometric ContractionMaleMuscle, SkeletalMuscle StrengthPolyestersQuadriceps MuscleTorquePolyestersMagnetic resonance imagingMuscle volumeQuadriceps femorisSupplementation

Identifiers

PMID36433662
PMCPMC10078466
OpenAlexW4310296329

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.