Evidence map›Paper›PMID 36433166›Full record

ArticlePolymers2022

Novel Polymeric Nanomaterial Based on Poly(Hydroxyethyl Methacrylate-Methacryloylamidophenylalanine) for Hypertension Treatment: Properties and Drug Release Characteristics.

Fevzi Bardakci, Kevser Kusat, Mohd Adnan, Riadh Badraoui, Mohammad Jahoor Alam, Mousa M Alreshidi, Arif Jamal Siddiqui, Manojkumar Sachidanandan, Sinan Akgöl

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Polymers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Fevzi BardakciDepartment of Biology, College of Science, University of Hail, Hail P.O. Box 2440, Saudi Arabia.ORCID 0000-0003-3377-2763
Kevser KusatDepartment of Chemistry, Faculty of Science, Dokuz Eylül University, Izmir 35390, Turkey.ORCID 0000-0003-4700-7835
Mohd AdnanDepartment of Biology, College of Science, University of Hail, Hail P.O. Box 2440, Saudi Arabia.ORCID 0000-0002-7080-6822
Riadh BadraouiDepartment of Biology, College of Science, University of Hail, Hail P.O. Box 2440, Saudi Arabia.ORCID 0000-0001-9054-7744
Mohammad Jahoor AlamDepartment of Biology, College of Science, University of Hail, Hail P.O. Box 2440, Saudi Arabia.ORCID 0000-0003-0144-6517
Mousa M AlreshidiDepartment of Biology, College of Science, University of Hail, Hail P.O. Box 2440, Saudi Arabia.ORCID 0000-0002-3763-9698
Arif Jamal SiddiquiDepartment of Biology, College of Science, University of Hail, Hail P.O. Box 2440, Saudi Arabia.ORCID 0000-0002-6236-0920
Manojkumar SachidanandanDepartment of Oral Radiology, College of Dentistry, University of Hail, Hail P.O. Box 2440, Saudi Arabia.
Sinan AkgölDepartment of Biochemistry, Faculty of Science, Ege University, Izmir 35040, Turkey.ORCID 0000-0002-8528-1854
University of Ha'il · SADokuz Eylül University · TRSabancı Üniversitesi · TRTunis University · TN

Funding

This research has been funded by the Scientific Research Deanship at the University of Ha'il-Saudi Arabia through project number MDR-22019 MDR-22019
6 · The paper itself

Abstract

In this study, a novel polymeric nanomaterial was synthesized and characterized, and it its potential usability in hypertension treatment was demonstrated. For these purposes, a poly(hydroxyethyl methacrylate-methacryloylamidophenylalanine)-based polymeric nanomaterial (p(HEMPA)) was synthesized using a mini-emulsion polymerization technique. The nanomaterials were characterized using scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), and zeta size analysis. The synthesized p(HEMPA) nanomaterial had a diameter of about 113 nm. Amlodipine-binding studies were optimized by changing the reaction conditions. Under optimum conditions, amlodipine's maximum adsorption value (Qmax) of the p(HEMPA) nanopolymer was found to be 145.8 mg/g. In vitro controlled drug release rates of amlodipine, bound to the nanopolymer at the optimum conditions, were studied with the dialysis method in a simulated gastrointestinal system with pH values of 1.2, 6.8 and 7.4. It was found that 99.5% of amlodipine loaded on the nanomaterial was released at pH 7.4 and 72 h. Even after 72 h, no difference was observed in the release of AML. It can be said that the synthesized nanomaterial is suitable for oral amlodipine release. In conclusion, the synthesized nanomaterial was studied for the first time in the literature as a drug delivery system for use in the treatment of hypertension. In addition, AML-p(HEMPA) nanomaterials may enable less frequent drug uptake, have higher bioavailability, and allow for prolonged release with minimal side effects.

Indexed as

amlodipinedrug releasehypertensionnanopolymerpolymeric nanomaterials

Identifiers

PMID36433166
PMCPMC9693067
OpenAlexW4309683984

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.