Evidence map›Paper›PMID 36433156›Full record

ArticlePolymers2022

Synthesis and Characterization of PU/PLCL/CMCS Electrospun Scaffolds for Skin Tissue Engineering.

Xiang Gao, Meiling Wen, Yang Liu, Tian Hou, Bin Niu, Meiwen An

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Polymers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xiang GaoCollege of Biomedical Engineering, Taiyuan University of Technology, Taiyuan 030024, China.
Meiling WenCollege of Biomedical Engineering, Taiyuan University of Technology, Taiyuan 030024, China.
Yang LiuCollege of Biomedical Engineering, Taiyuan University of Technology, Taiyuan 030024, China.
Tian HouCollege of Biomedical Engineering, Taiyuan University of Technology, Taiyuan 030024, China.ORCID 0000-0002-2610-2377
Bin NiuCollege of Biomedical Engineering, Taiyuan University of Technology, Taiyuan 030024, China.
Meiwen AnCollege of Biomedical Engineering, Taiyuan University of Technology, Taiyuan 030024, China.

Funding

National Natural Science Foundation of China 31870934
6 · The paper itself

Abstract

As tissue regeneration material, electrospun fibers can mimic the microscale and nanoscale structure of the natural extracellular matrix (ECM), which provides a basis for cell growth and achieves organic integration with surrounding tissues. At present, the challenge for researchers is to develop a bionic scaffold for the regeneration of the wound area. In this paper, polyurethane (PU) is a working basis for the subsequent construction of tissue-engineered skin. poly(L-lactide-co-caprolactone) (PLCL)/carboxymethyl chitosan (CMCS) composite fibers were prepared via electrospinning and cross-linked by glutaraldehyde. The effect of CMCS content on the surface morphology, mechanical properties, hydrophilicity, swelling degree, and cytocompatibility were explored, aiming to assess the possibility of composite scaffolds for tissue engineering applications. The results showed that randomly arranged electrospun fibers presented a smooth surface. All scaffolds exhibited sufficient tensile strength (5.30-5.60 MPa), Young's modulus (2.62-4.29 MPa), and swelling degree for wound treatment. The addition of CMCS improved the hydrophilicity and cytocompatibility of the scaffolds.

Indexed as

carboxymethyl chitosancytocompatibilityelectrospun fiberpoly(L-lactide-co-caprolactone)polyurethaneskin tissue engineering

Identifiers

PMID36433156
PMCPMC9699124

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.