Evidence map›Paper›PMID 36432968›Full record

ArticlePolymers2022

Gold-Nanoparticle-Enhanced Radio-Fluorogenic Hydrogel Sensor for Low Radiation Doses in Clinical Radiotherapy.

Xingyu Dong, Yuan Tian, Fengqing Wang, Chong Chen, Yunlong Wang, Jun Ma

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Polymers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Xingyu DongCollege of Materials Science and Technology, Nanjing University of Aeronautics and Astronautics, Nanjing 211106, China.
Yuan TianCollege of Materials Science and Technology, Nanjing University of Aeronautics and Astronautics, Nanjing 211106, China.
Fengqing WangCollege of Materials Science and Technology, Nanjing University of Aeronautics and Astronautics, Nanjing 211106, China.
Chong ChenCollege of Materials Science and Technology, Nanjing University of Aeronautics and Astronautics, Nanjing 211106, China.
Yunlong WangCollege of Materials Science and Technology, Nanjing University of Aeronautics and Astronautics, Nanjing 211106, China.ORCID 0000-0001-7455-8064
Jun MaCollege of Materials Science and Technology, Nanjing University of Aeronautics and Astronautics, Nanjing 211106, China.
Nanjing University of Aeronautics and Astronautics · CN

Funding

Fundamental Research Funds for the Central Universities NE2020006, NT2022020National Natural Science Foundation of China 21906083, 22006067, 11975122Natural Science Foundation of Jiangsu Province BK20190384Scientific and Technological Innovation Special Fund for Carbon Peak and Carbon Neutrality of Jiangsu Province BK20220026
6 · The paper itself

Abstract

Radio-fluorogenic hydrogel dosimeters are urgently needed in radiotherapy for 3D dose verification. However, few hydrogel sensors have been reported at low absorbed doses under 2 Gy which meets the requirements of clinical practice. Here, we report a new type of gold-nanoparticle-enhanced radio-fluorogenic agarose hydrogel with coumarin as the dose-responsive material. An optimal composition of 3 wt% of agarose, 0.1 mM of gold nanoparticles, and 0.5 mM coumarin was selected. The addition of gold nanoparticles enhanced the hydroxyl radicals generated from the radiolysis of water, which can react with coumarin and generate fluorescent 7-hydroxy-coumarin and, eventually, achieve low-dose verification of 0-2.4 Gy with a high linear correlation coefficient. These findings provide an effective method for 3D dose verification, and will inspire the development of other radio-fluorogenic sensing hydrogels as well.

Indexed as

gold nanoparticlesradiation dosimetryradio-fluorogenic hydrogelradiotherapy

Identifiers

PMID36432968
PMCPMC9694710
OpenAlexW4308703690

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.