Evidence map›Paper›PMID 36432941›Full record

ArticlePolymers2022

Acceleration of Bone Fracture Healing through the Use of Bovine Hydroxyapatite or Calcium Lactate Oral and Implant Bovine Hydroxyapatite-Gelatin on Bone Defect Animal Model.

Aniek Setiya Budiatin, Junaidi Khotib, Samirah Samirah, Chrismawan Ardianto, Maria Apriliani Gani, Bulan Rhea Kaulika Hadinar Putri, Huzaifah Arofik, Rizka Nanda Sadiwa, Indri Lestari, Yusuf Alif Pratama and 2 more

Open access · goldAbstract read
In one paragraph

Article in Polymers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

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  8. The potential calcium content of anchovyJournal of oral and maxillofacial pathology : JOMFP
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Aniek Setiya BudiatinDepartment of Pharmacy Practice, Faculty of Pharmacy, Universitas Airlangga, Surabaya 60115, Indonesia.ORCID 0000-0002-1897-4159
Junaidi KhotibDepartment of Pharmacy Practice, Faculty of Pharmacy, Universitas Airlangga, Surabaya 60115, Indonesia.ORCID 0000-0002-8468-8441
Samirah SamirahDepartment of Pharmacy Practice, Faculty of Pharmacy, Universitas Airlangga, Surabaya 60115, Indonesia.ORCID 0000-0002-7918-5487
Chrismawan ArdiantoDepartment of Pharmacy Practice, Faculty of Pharmacy, Universitas Airlangga, Surabaya 60115, Indonesia.ORCID 0000-0003-3713-7900
Maria Apriliani GaniDepartment of Pharmacy Practice, Faculty of Pharmacy, Universitas Airlangga, Surabaya 60115, Indonesia.ORCID 0000-0001-5811-9301
Bulan Rhea Kaulika Hadinar PutriDepartment of Pharmacy Practice, Faculty of Pharmacy, Universitas Airlangga, Surabaya 60115, Indonesia.ORCID 0000-0002-2962-017X
Huzaifah ArofikDepartment of Pharmacy Practice, Faculty of Pharmacy, Universitas Airlangga, Surabaya 60115, Indonesia.
Rizka Nanda SadiwaDepartment of Pharmacy Practice, Faculty of Pharmacy, Universitas Airlangga, Surabaya 60115, Indonesia.
Indri LestariDepartment of Pharmacy Practice, Faculty of Pharmacy, Universitas Airlangga, Surabaya 60115, Indonesia.
Yusuf Alif PratamaDepartment of Pharmacy Practice, Faculty of Pharmacy, Universitas Airlangga, Surabaya 60115, Indonesia.ORCID 0000-0003-2920-6881
Erreza RahadiansyahDepartment of Orthopaedics and Traumatology, Faculty of Medicine, Universitas Airlangga, Surabaya 60131, Indonesia.
Imam SusiloDepartment of Anatomical Pathology, Faculty of Medicine, Universitas Airlangga, Surabaya 60131, Indonesia.
Airlangga University · ID

Funding

Lembaga Pengelola Dana Pendidikan Ministry of Finance of the Republic of Indonesia via Pendanaan Riset Inovatif Produktif (RISPRO) Batch 1 Tahun 2019 KEP-51/LPDP/2019
6 · The paper itself

Abstract

Bone grafts a commonly used therapeutic technique for the reconstruction and facilitation of bone regeneration due to fractures. BHA-GEL (bovine hydroxyapatite-gelatin) pellet implants have been shown to be able accelerate the process of bone repair by looking at the percentage of new bone, and the contact between the composite and bone. Based on these results, a study was conducted by placing BHA-GEL (9:1) pellet implants in rabbit femoral bone defects, accompanied by 500 mg oral supplement of BHA or calcium lactate to determine the effectiveness of addition supplements. The research model used was a burr hole defect model with a diameter of 4.2 mm in the cortical part of the rabbit femur. On the 7th, 14th and 28th days after treatment, a total of 48 New Zealand rabbits were divided into four groups, namely defect (control), implant, implant + oral BHA, and implant + oral calcium lactate. Animal tests were terminated and evaluated based on X-ray radiology results,

Indexed as

BHA–GEL pelletbone remodelingbovine hydroxyapatitecalcium lactatedefect

Identifiers

PMID36432941
PMCPMC9698469
OpenAlexW4308866773

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.