Evidence map›Paper›PMID 36432925›Full record

ArticlePolymers2022

Tailored Supersaturable Immediate Release Behaviors of Hypotensive Supersaturating Drug-Delivery Systems Combined with Hot-Melt Extrusion Technique and Self-Micellizing Polymer.

Huan Yu, Yinghui Ma, Yanfei Zhang, Huifeng Zhang, Lili Zuo, Chengyi Hao, Weilun Yu, Xiaoying Lin, Yong Zhang, Xianrong Qi and 1 more

Open access · goldAbstract read
In one paragraph

Article in Polymers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Huan YuSchool of Pharmacy, Jilin Medical University, Jilin 132013, China.
Yinghui MaSchool of Pharmacy, Jilin Medical University, Jilin 132013, China.
Yanfei ZhangSchool of Pharmacy, Jilin Medical University, Jilin 132013, China.
Huifeng ZhangSchool of Pharmacy, Jilin Medical University, Jilin 132013, China.
Lili ZuoSchool of public health, Jilin Medical University, Jilin 132013, China.
Chengyi HaoSchool of Pharmacy, Jilin Medical University, Jilin 132013, China.
Weilun YuDepartment of Biomedical Engineering, Jilin Medical University, Jilin 132013, China.
Xiaoying LinSchool of Pharmacy, Jilin Medical University, Jilin 132013, China.
Yong ZhangSchool of Life Science, Jilin University, 2699 Qianjin Street, Changchun 130012, China.ORCID 0000-0001-6577-5235
Xianrong QiDepartment of Pharmaceutics, School of Pharmaceutical Science, Peking University, Beijing 100191, China.ORCID 0000-0002-8264-0794
Nianqiu ShiSchool of Pharmacy, Jilin Medical University, Jilin 132013, China.
Jilin Medical University · CNJilin University · CNPeking University · CNYanbian University · CN

Funding

College Students' Innovation Project of Jilin Province 202013706026Doctoral Research Startup Fund Project of Jilin Medical University JYBS2021002LKNational Natural Science Foundation of China 82172593National Natural Science Foundation of China 82204729Science and Technology Development Program of Jilin City in Jilin Province of China 201831739Science and Technology Development Program of Jilin City in Jilin Province of China 20200104067Science and Technology Development Program of Jilin Province of China 20160520046JHScience and Technology Development Program of Jilin Province of China 20210101430JCScientific Research Foundation of the Education Department of Jilin Province of China 2015-401Scientific Research Foundation of the Education Department of Jilin Province of China JJKH20191072KJ
6 · The paper itself

Abstract

The short-term immediate release of supersaturated drug-delivery systems (SDDSs) presents an interesting process that can be tailored to multi-stage release events including initial release after dosing and dissolution, evolved release over longer dissolution periods for biological absorption, and terminal release following the end of immediate release. However, although comprehensive analysis of these critical release behaviors is often ignored yet essential for understanding the supersaturable immediate-release events for supersaturable solid formations when employing new techniques or polymers matched to a particular API. Hot-melt extrusion (HME) has become a popular continuous thermodynamic disordering technique for amorphization. The self-micellizing polymer Soluplus

Indexed as

amorphization and supersaturationhot-melt extrusion techniquehypotensive supersaturating drug-delivery systemsself-micellizing polymer strategytailored supersaturable immediate-release behaviors

Identifiers

PMID36432925
PMCPMC9693352
OpenAlexW4308522463

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.