Evidence map›Paper›PMID 36432714›Full record

ArticlePharmaceutics2022

Drug Transport System Based on Phospholipid Nanoparticles: Production Technology and Characteristics.

Elena G Tikhonova, Maxim A Sanzhakov, Yulia A Tereshkina, Lyubov V Kostryukova, Yulia Yu Khudoklinova, Nadezhda A Orlova, Daria V Bobrova, Olga M Ipatova

Abstract read
In one paragraph

Article in Pharmaceutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Elena G TikhonovaInstitute of Biomedical Chemistry, 10 Pogodinskaya St., 119121 Moscow, Russia.
Maxim A SanzhakovInstitute of Biomedical Chemistry, 10 Pogodinskaya St., 119121 Moscow, Russia.
Yulia A TereshkinaInstitute of Biomedical Chemistry, 10 Pogodinskaya St., 119121 Moscow, Russia.
Lyubov V KostryukovaInstitute of Biomedical Chemistry, 10 Pogodinskaya St., 119121 Moscow, Russia.ORCID 0000-0002-1607-2936
Yulia Yu KhudoklinovaInstitute of Biomedical Chemistry, 10 Pogodinskaya St., 119121 Moscow, Russia.ORCID 0000-0002-7197-3753
Nadezhda A OrlovaInstitute of Biomedical Chemistry, 10 Pogodinskaya St., 119121 Moscow, Russia.
Daria V BobrovaInstitute of Biomedical Chemistry, 10 Pogodinskaya St., 119121 Moscow, Russia.
Olga M IpatovaInstitute of Biomedical Chemistry, 10 Pogodinskaya St., 119121 Moscow, Russia.

Funding

The Ministry of Education and Science of the Russian Federation Agreement No. 075-15-2021-933, unique project ID: RF00121X0004
6 · The paper itself

Abstract

One of the current trends in modern pharmaceuticals is the supply of drugs by transport systems. The use of delivery systems allows to increase the therapeutic efficacy, tolerability, and safety of drug therapy. Liposomes, polymer nanoparticles, carbon nanoparticles, blood cells, metal nanoparticles, oxides, etc., are used as transport systems. This work is aimed at obtaining a finished technological product based on soy phospholipids with particle size in the nanometer range and reproducible characteristics (size, charge). For this purpose, we carried out investigations to select the optimal conditions of technological process. The developed technology makes it possible to obtain phospholipid nanoparticles without the use of any solubilizers and/or surfactants, which increases its practical relevance for further work. The versatility of the technology is demonstrated by the example of incorporation of drugs of various chemical nature and pharmacotherapeutic groups.

Indexed as

dispersiondosage formphospholipid nanoparticlessoy phosphatidylcholinetechnological factors of lyophilization

Identifiers

PMID36432714
PMCPMC9695503

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.