Evidence map›Paper›PMID 36432706›Full record

ArticlePharmaceutics2022

Selection of an Aptamer against the Enzyme 1-deoxy-D-xylulose-5-phosphate Reductoisomerase from

Carlota Roca, Yunuen Avalos-Padilla, Beatriz Prieto-Simón, Valentín Iglesias, Miriam Ramírez, Santiago Imperial, Xavier Fernàndez-Busquets

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Apicoplast-Resident Processes: Exploiting the Chink in the Armour ofAdvances in pharmacological and pharmaceutical sciences · 2024
    Review
  6. Proposition ofCombinatorial chemistry & high throughput screening · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Carlota RocaBarcelona Institute for Global Health (ISGlobal), Hospital Clínic, Universitat de Barcelona, Rosselló 149-153, 08036 Barcelona, Spain.
Yunuen Avalos-PadillaBarcelona Institute for Global Health (ISGlobal), Hospital Clínic, Universitat de Barcelona, Rosselló 149-153, 08036 Barcelona, Spain.ORCID 0000-0003-4074-5624
Beatriz Prieto-SimónDepartment of Electronic Engineering, Universitat Rovira i Virgili, 43007 Tarragona, Spain.ORCID 0000-0001-8016-1565
Valentín IglesiasBarcelona Institute for Global Health (ISGlobal), Hospital Clínic, Universitat de Barcelona, Rosselló 149-153, 08036 Barcelona, Spain.ORCID 0000-0002-6133-0869
Miriam RamírezBarcelona Institute for Global Health (ISGlobal), Hospital Clínic, Universitat de Barcelona, Rosselló 149-153, 08036 Barcelona, Spain.
Santiago ImperialNanoscience and Nanotechnology Institute (IN2UB), University of Barcelona, Martí i Franquès 1, 08028 Barcelona, Spain.ORCID 0000-0001-8749-1428
Xavier Fernàndez-BusquetsBarcelona Institute for Global Health (ISGlobal), Hospital Clínic, Universitat de Barcelona, Rosselló 149-153, 08036 Barcelona, Spain.ORCID 0000-0002-4622-9631
Institute for Bioengineering of Catalonia · ESBarcelona Institute for Global Health · ESInstitució Catalana de Recerca i Estudis Avançats · ESUniversitat Autònoma de Barcelona · ESUniversitat de Barcelona · ES

Funding

Generalitat de Catalunya 2017-SGR-908Schlumberger Foundation Faculty N/ASpanish Ministry of Science, Innovation, and Universities RTI2018-094579-B-I00Spanish State Research Agency RTI2018-094579-B-I00Unión Iberoamericana de Universidades USP-05-2019
6 · The paper itself

Abstract

The methyl erythritol phosphate (MEP) pathway of isoprenoid biosynthesis is essential for malaria parasites and also for several human pathogenic bacteria, thus representing an interesting target for future antimalarials and antibiotics and for diagnostic strategies. We have developed a DNA aptamer (D10) against

Indexed as

1-deoxy-D-xylulose-5-phosphate reductoisomeraseDNA aptamersmethyl erythritol phosphate pathwayPlasmodium

Identifiers

PMID36432706
PMCPMC9695703
OpenAlexW4309683778

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.