Evidence map›Paper›PMID 36432688›Full record

ReviewPharmaceutics2022

Fluorescent Multifunctional Organic Nanoparticles for Drug Delivery and Bioimaging: A Tutorial Review.

Guillem Vargas-Nadal, Mariana Köber, Audrey Nsamela, Francesca Terenziani, Cristina Sissa, Silvia Pescina, Fabio Sonvico, Amirah Mohd Gazzali, Habibah A Wahab, Luca Grisanti and 9 more

Abstract readReview
In one paragraph

Review in Pharmaceutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Nanoparticles-Delivered Circular RNA Strategy as a Novel Antitumor Approach.International journal of molecular sciences · 2024
    Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
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  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Guillem Vargas-NadalDepartment of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, Parco Area delle Scienze 17A, 43124 Parma, Italy.
Mariana KöberInstitut de Ciència de Materials de Barcelona (ICMAB-CSIC), 08193 Bellaterra, Spain.ORCID 0000-0001-9962-7900
Audrey NsamelaElvesys SAS, 172 Rue de Charonne, 75011 Paris, France.
Francesca TerenzianiDepartment of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, Parco Area delle Scienze 17A, 43124 Parma, Italy.ORCID 0000-0001-5162-9210
Cristina SissaDepartment of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, Parco Area delle Scienze 17A, 43124 Parma, Italy.ORCID 0000-0003-1972-1281
Silvia PescinaADDRes Lab, Department of Food and Drug, University of Parma, Parco Area delle Scienze 27A, 43124 Parma, Italy.ORCID 0000-0002-6131-4375
Fabio SonvicoADDRes Lab, Department of Food and Drug, University of Parma, Parco Area delle Scienze 27A, 43124 Parma, Italy.ORCID 0000-0001-7372-1456
Amirah Mohd GazzaliSchool of Pharmaceutical Sciences, Universiti Sains Malaysia, USM, Gelugor 11800, Penang, Malaysia.ORCID 0000-0003-4469-1969
Habibah A WahabSchool of Pharmaceutical Sciences, Universiti Sains Malaysia, USM, Gelugor 11800, Penang, Malaysia.ORCID 0000-0002-8353-8679
Luca GrisantiDivision of Theoretical Physics, Ruđer Bošković Institute, Bijenička Cesta 54, 10000 Zagreb, Croatia.
María Eugenia OliveraUnidad de Investigación y Desarrollo en Tecnología Farmacéutica (UNITEFA), CONICET and Departamento de Ciencias Farmacéuticas, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Ciudad Universitaria, Córdoba 5000, Argentina.ORCID 0000-0002-2831-7961
María Celeste PalenaUnidad de Investigación y Desarrollo en Tecnología Farmacéutica (UNITEFA), CONICET and Departamento de Ciencias Farmacéuticas, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Ciudad Universitaria, Córdoba 5000, Argentina.
María Laura GuzmanUnidad de Investigación y Desarrollo en Tecnología Farmacéutica (UNITEFA), CONICET and Departamento de Ciencias Farmacéuticas, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Ciudad Universitaria, Córdoba 5000, Argentina.
Laura Carolina Luciani-GiacobbeUnidad de Investigación y Desarrollo en Tecnología Farmacéutica (UNITEFA), CONICET and Departamento de Ciencias Farmacéuticas, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Ciudad Universitaria, Córdoba 5000, Argentina.
Alvaro Jimenez-KairuzUnidad de Investigación y Desarrollo en Tecnología Farmacéutica (UNITEFA), CONICET and Departamento de Ciencias Farmacéuticas, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Ciudad Universitaria, Córdoba 5000, Argentina.ORCID 0000-0003-1659-7983
Nora VentosaInstitut de Ciència de Materials de Barcelona (ICMAB-CSIC), 08193 Bellaterra, Spain.ORCID 0000-0002-8008-4974
Imma RateraInstitut de Ciència de Materials de Barcelona (ICMAB-CSIC), 08193 Bellaterra, Spain.ORCID 0000-0002-1464-9789
Kevin D BelfieldDepartment of Chemistry and Environmental Science, New Jersey Institute of Technology, 323 Martin Luther King Jr. Blvd., Newark, NJ 07102, USA.
Ben M MaozDepartment of Biomedical Engineering, Tel Aviv University, Tel Aviv 6997801, Israel.ORCID 0000-0002-3823-7682

Funding

European Union 101007804
6 · The paper itself

Abstract

Fluorescent organic nanoparticles (FONs) are a large family of nanostructures constituted by organic components that emit light in different spectral regions upon excitation, due to the presence of organic fluorophores. FONs are of great interest for numerous biological and medical applications, due to their high tunability in terms of composition, morphology, surface functionalization, and optical properties. Multifunctional FONs combine several functionalities in a single nanostructure (emission of light, carriers for drug-delivery, functionalization with targeting ligands, etc.), opening the possibility of using the same nanoparticle for diagnosis and therapy. The preparation, characterization, and application of these multifunctional FONs require a multidisciplinary approach. In this review, we present FONs following a tutorial approach, with the aim of providing a general overview of the different aspects of the design, preparation, and characterization of FONs. The review encompasses the most common FONs developed to date, the description of the most important features of fluorophores that determine the optical properties of FONs, an overview of the preparation methods and of the optical characterization techniques, and the description of the theoretical approaches that are currently adopted for modeling FONs. The last part of the review is devoted to a non-exhaustive selection of some recent biomedical applications of FONs.

Indexed as

bioimagingdrug deliveryfluorescencefluorescence microscopyfluorophoresFONs manufacturingorganic nanoparticlestheoretical simulations of nanoparticles

Identifiers

PMID36432688
PMCPMC9698844

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.