Evidence map›Paper›PMID 36432650›Full record

ArticlePharmaceutics2022

Fabrication of Functional bioMOF-100 Prototype as Drug Delivery System for Breast Cancer Therapy.

Renata Carolina Alves, Richard Perosa Fernandes, Renan Lira de Farias, Patricia Bento da Silva, Raquel Santos Faria, Christian Rafael Quijia, Regina Célia Galvão Frem, Ricardo Bentes Azevedo, Marlus Chorilli

Abstract read
In one paragraph

Article in Pharmaceutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. BioMOF-Based Anti-Cancer Drug Delivery Systems.Nanomaterials (Basel, Switzerland) · 2023
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Renata Carolina AlvesDepartment of Drugs and Medicines, School of Pharmaceutical Sciences, São Paulo State University (UNESP), Rodovia Araraquara Jau, Km 01-s/n-Campos Ville, Araraquara 14800-903, Brazil.
Richard Perosa FernandesDepartment of Chemistry, Federal University of Mato Grosso (UFMT), Cuiabá 78060-900, Brazil.ORCID 0000-0002-4446-3037
Renan Lira de FariasDepartament of Chemical, Pontifícia Universidade Católica do Rio de Janeiro, Rio de Janeiro 22451-900, Brazil.ORCID 0000-0001-5522-7913
Patricia Bento da SilvaDepartment of Genetics and Morphology, Institute of Biological Sciences, University of Brasilia (UnB), Campus Universitario Darcy Ribeiro-Asa Norte, Brasilia 70910-900, Brazil.
Raquel Santos FariaDepartment of Genetics and Morphology, Institute of Biological Sciences, University of Brasilia (UnB), Campus Universitario Darcy Ribeiro-Asa Norte, Brasilia 70910-900, Brazil.
Christian Rafael QuijiaDepartment of Drugs and Medicines, School of Pharmaceutical Sciences, São Paulo State University (UNESP), Rodovia Araraquara Jau, Km 01-s/n-Campos Ville, Araraquara 14800-903, Brazil.
Regina Célia Galvão FremChemistry Institute, São Paulo State University (UNESP), Campus Araraquara, Araraquara 14800-060, Brazil.
Ricardo Bentes AzevedoDepartment of Genetics and Morphology, Institute of Biological Sciences, University of Brasilia (UnB), Campus Universitario Darcy Ribeiro-Asa Norte, Brasilia 70910-900, Brazil.ORCID 0000-0002-2137-9588
Marlus ChorilliDepartment of Drugs and Medicines, School of Pharmaceutical Sciences, São Paulo State University (UNESP), Rodovia Araraquara Jau, Km 01-s/n-Campos Ville, Araraquara 14800-903, Brazil.ORCID 0000-0002-6698-0545

Funding

São Paulo Research Foundation 2017/26065-2
6 · The paper itself

Abstract

Breast cancer is the most frequent cause of cancer death in women, representing the fifth leading cause of cancer death overall. Therefore, the growing search for the development of new treatments for breast cancer has been developed lately as well as drug delivery systems such as biocompatible metal-organic Frameworks (bio-MOFs). These may be promising and attractive for drug incorporation and release. The present study aims to develop a drug carrier system RCA (bioMOF-100 submitted to the activation process) containing incorporated curcumin (CCM), whose material surface is coated with folic acid molecules (FA) to promote the targeting of drug carrier systems to the tumor region. They were synthesized and characterized using several characterization techniques. The materials were submitted to drug encapsulation tests, whose encapsulation efficiency was 32.80% for CCM@RCA-1D. Using the

Indexed as

bio-MOFscancercurcumindelivery systemsfunctionalization

Identifiers

PMID36432650
PMCPMC9699488

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.