ReviewNutrients2022
Iron Supplementation in Pregnancy and Risk of Gestational Diabetes: A Narrative Review.
Review in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 28 citations in OpenAlex.
- Effect of Prenatal Iron Supplementation Adapted to Hemoglobin Levels in Early Pregnancy on Fetal and Neonatal Growth-ECLIPSES Study.Nutrients · 2024Trial
- Variation in antenatal anaemia guidelines across the NHS in the United Kingdom: A cross-sectional study.British journal of haematology · 2026Article
- Maternal Nutrition During Pregnancy and Fetal Outcome, Short- and Long-Term Health Effects: A Narrative Review.Nutrients · 2026Review
- Research Progress on Ferroptosis Regulation of Female Reproduction.Biological trace element research · 2026Review
- Interconnected Developmental Trajectories of the Brain, Gut, and Sleep in Early Life: The First 1000 Days of Nutritional Opportunity.Nutrients · 2026Review
- Iron deficiency anemia in pregnancy and related complications with specific insight in Rivers State, Nigeria: a narrative review.Annals of medicine and surgery (2012) · 2025Review
- A prospective study of early pregnancy metal concentrations and gestational diabetes mellitus based on a birth cohort in Northwest China.BMC pregnancy and childbirth · 2025Article
- Hematologic Complications of Pregnancy.European journal of haematology · 2025Review
- Associations between serum ferritin levels and gestational diabetes mellitus among a non-anemic population.BMC pregnancy and childbirth · 2025Article
- Focus on Cell Apoptosis, Pyroptosis and Ferroptosis to Explore Strategic Breakthrough for GDM.Journal of inflammation research · 2025Review
- Micro-nutrient sufficiency in mothers and babies: management of deficiencies while avoiding overload during pregnancy.Frontiers in nutrition · 2025Review
- Iron Deficiency Anaemia in Pregnancy: A Narrative Review from a Clinical Perspective.Diagnostics (Basel, Switzerland) · 2024Review
- The Role of Maternal Serum Ferritin in Gestational Diabetes Mellitus in Southeast Asia.Cureus · 2024Article
- Association of mid-pregnancy ferritin levels with postpartum glucose metabolism in women with gestational diabetes.Nutrition & diabetes · 2024Article
- Scientific opinion on the tolerable upper intake level for iron.EFSA journal. European Food Safety Authority · 2024Article
- Ferritin and iron supplements in gestational diabetes mellitus: less or more?European journal of nutrition · 2024Review
- Dietary supplements, guideline alignment and biochemical nutrient status in pregnancy: Findings from the Queensland Family Cohort pilot study.Maternal & child nutrition · 2024Observational
- Anaemia at mid-pregnancy is associated with prehypertension in late pregnancy among urban women.Health SA = SA Gesondheid · 2024Article
- Article
- Molecular pathways and nutrigenomic review of insulin resistance development in gestational diabetes mellitus.Frontiers in nutrition · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pregnant women frequently supplement their diets with iron to treat any cryptic anemia, on the assumption that if anemia is not present, there will be no negative consequences. However, in women who are already iron-replete, it has been suggested that this can lead to iron overload and an increased risk of certain pregnancy complications. One such complication is gestational diabetes. Fourteen clinical trials, case-control or cohort studies (found using Pubmed/Scopus/Web of Science) have investigated links between iron supplementation in pregnancy and risk of gestational diabetes, several of them finding significant associations with increased risk. Potential mechanisms include increased oxidative stress leading to insulin resistance and inadequate compensatory insulin secretion. Current evidence suggests that dietary supplementation with iron in pregnancy may increase a pregnant woman's chance of developing gestational diabetes, although available evidence is somewhat contradictory, and the magnitude of any increased risk appears relatively small. Meta-analyses have suggested the presence of significant heterogeneity in results between studies, urging a degree of caution in interpreting these results. It is currently suggested that advice to pregnant women about whether to supplement their diets with iron or not should consider both their current iron status and their other established risk factors for gestational diabetes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.