Evidence map›Paper›PMID 36432457›Full record

ReviewNutrients2022

Nutraceutical Approaches to Dyslipidaemia: The Main Formulative Issues Preventing Efficacy.

Alessandro Colletti, Andrea Fratter, Marzia Pellizzato, Giancarlo Cravotto

Open access · goldAbstract readReview
In one paragraph

Review in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

  1. Co-Extraction of Policosanols and Phytosterols fromMolecules (Basel, Switzerland) · 2026
    Article
  2. Review
  3. Clinical pharmacology : advances and applications · 2025
    Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Alessandro CollettiDepartment of Science and Drug Technology, University of Turin, 10124 Turin, Italy.
Andrea FratterItalian Society of Nutraceutical Formulators (SIFNut), 31033 Treviso, Italy.ORCID 0000-0001-8093-3019
Marzia PellizzatoItalian Society of Nutraceutical Formulators (SIFNut), 31033 Treviso, Italy.
Giancarlo CravottoDepartment of Science and Drug Technology, University of Turin, 10124 Turin, Italy.ORCID 0000-0001-7574-7350
Italian Society of Physiotherapy · ITUniversity of Padua · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Currently, the nutraceutical approach to treat dyslipidaemia is increasing in use, and in many cases is used by physicians as the first choice in the treatment of patients with borderline values. Nutraceuticals represent an excellent opportunity to treat the preliminary conditions not yet showing the pathological signs of dyslipidaemia. Their general safety, the patient's confidence, the convincing proof of efficacy and the reasonable costs prompted the market of new preparations. Despite this premise, many nutraceutical products are poorly formulated and do not meet the minimum requirements to ensure efficacy in normalizing blood lipid profiles, promoting cardiovascular protection, and normalizing disorders of glycemic metabolism. In this context, bioaccessibility and bioavailability of the active compounds is a crucial issue. Little attention is paid to the proper formulations needed to improve the overall bioavailability of the active molecules. According to these data, many products prove to be insufficient to ensure full enteric absorption. The present review analysed the literature in the field of nutraceuticals for the treatment of dyslipidemia, focusing on resveratrol, red yeast rice, berberine, and plant sterols, which are among the nutraceuticals with the greatest formulation problems, highlighting bioavailability and the most suitable formulations.

Indexed as

BerberineDyslipidemiasPhytosterolsDietary SupplementsHumansLipidsBerberineLipidsPhytosterolsbioaccesibilitybioavailabilitydyslipidaemianutraceuticalsnutritional supplements

Identifiers

PMID36432457
PMCPMC9696395
OpenAlexW4309011025

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.