ArticleNutrients2022
Threshold Ferritin Concentrations Reflecting Early Iron Deficiency Based on Hepcidin and Soluble Transferrin Receptor Serum Levels in Patients with Absolute Iron Deficiency.
Article in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Navigating Anemia in Solid and Hematologic Malignancies: A Comprehensive Review of Classical and Emerging Therapies.European journal of haematology · 2026Review
- Nonanemic Iron Deficiency: Exercise Performance Recovery After Iron Repletion in Collegiate Athlete.JACC. Case reports · 2026Article
- The hidden link between iron deficiency and celiac disease: a clinical perspective.Frontiers in immunology · 2026Article
- Iron Deficiency Diagnosis in Sub-Saharan Africa: Challenges, Barriers, and Opportunities.Anemia · 2026Review
- Iron deficiency and nutritional status in heart failure with reduced ejection fraction: a cross-sectional study.Cardiology journal · 2026Article
- Review
- Cost-Effectiveness of Ferritin Screening Thresholds for Iron Deficiency in Reproductive-Age Women.American journal of hematology · 2025Article
- Diagnosis and management of iron deficiency in females.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2025Review
- Iron Deficiency in Collegiate Athletes Obtaining Preparticipation Hemoglobinopathy Screening in the Upper Midwest.Pediatric blood & cancer · 2025Article
- Impact of obesity on iron metabolism and the effect of intravenous iron supplementation in obese patients with absolute iron deficiency.Scientific reports · 2025Article
- Diagnostics: Markers of Body Iron Status.Advances in experimental medicine and biology · 2025Review
- Is It Time to Alter the Standard of Care for Iron Deficiency/Iron Deficiency Anemia in Reproductive-Age Women?Biomedicines · 2024Review
- Conventional and complementary alternative medicine therapies for renal anemia: a literature review.Frontiers in endocrinology · 2024Review
- Sex, lies, and iron deficiency: a call to change ferritin reference ranges.Hematology. American Society of Hematology. Education Program · 2023Article
- The Ferritin, Hepcidin and Cytokines Link in the Diagnoses of Iron Deficiency Anaemia during Pregnancy: A Review.International journal of molecular sciences · 2023Review
- Dysregulation of iron metabolism modulators in virologically suppressed HIV-infected patients.Frontiers in immunology · 2022Article
- National Bleeding Disorder Foundation Clinical Practice Recommendations for Laboratory Screening of Iron Deficiency With and Without Anemia in the Inherited Bleeding Disorders Population.Haemophilia : the official journal of the World Federation of HemophiliaArticle
- Disparities in Discussion of Heavy Menstrual Bleeding in Patients With Iron Deficiency.Journal of primary care & community healthArticle
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
(1) Background: The serum ferritin cut-off to define absolute iron deficiency is not well-established. The aim of the present study was to determine a clinically relevant ferritin threshold by using early serum biomarkers of iron deficiency such as hepcidin and the soluble transferrin receptor; (2) Methods: Two hundred and twenty-eight asymptomatic subjects attending a hospital as outpatients between 1st April 2020 and 27th February 2022 were selected. Iron metabolism parameters as part of the blood analysis were requested by their doctor and included in the study. Then, they were classified into groups according to their ferritin levels and iron-related biomarkers in serum were determined, quantified, and compared between ferritin score groups and anemic subjects. (3) Results: Serum ferritin levels below 50 ng/mL establish the point from which the serum biomarker, the soluble transferrin receptor to hepcidin ratio (sTfR/Hep ratio), begins to correlate significantly with ferritin levels. (4) Conclusion: Ferritin levels ≤ 50 ng/mL are indicative of early iron deficiency; hence, this should be considered as a clinically relevant cut-off for iron deficiency.
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