Evidence map›Paper›PMID 36432424›Full record

Trial reportNutrients2022

Peripheral T-Cells, B-Cells, and Monocytes from Multiple Sclerosis Patients Supplemented with High-Dose Vitamin D Show Distinct Changes in Gene Expression Profiles.

Dohyup Kim, Emily E Witt, Simone Schubert, Elias Sotirchos, Pavan Bhargava, Ellen M Mowry, Karen Sachs, Biter Bilen, Lawrence Steinman, Avni Awani and 3 more

Open access · goldAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Dohyup KimNeurology and Neurological Sciences Department, Stanford University School of Medicine, Stanford, CA 94305, USA.
Emily E WittHarvard Medical School, Boston, MA 02115, USA.
Simone SchubertDepartment of Environmental Health and Safety, Stanford University School of Medicine, Stanford, CA 94305, USA.
Elias SotirchosDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Pavan BhargavaDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0002-7947-9418
Ellen M MowryDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Karen SachsNext Generation Analytics, Palo Alto, CA 94301, USA.
Biter BilenData Science and Engineering Consultant, Mountain View, CA 94041, USA.ORCID 0000-0001-9452-3512
Lawrence SteinmanNeurology and Neurological Sciences Department, Stanford University School of Medicine, Stanford, CA 94305, USA.
Avni AwaniNeurology and Neurological Sciences Department, Stanford University School of Medicine, Stanford, CA 94305, USA.
Zihuai HeNeurology and Neurological Sciences Department, Stanford University School of Medicine, Stanford, CA 94305, USA.
Peter A CalabresiDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0002-7776-6472
Keith Van HarenNeurology and Neurological Sciences Department, Stanford University School of Medicine, Stanford, CA 94305, USA.
Stanford University · USJohns Hopkins University · USHarvard University · USMountain View College · US

Funding

The effect of vitamin D3 on markers of oxidative stress in boys with X-linked ALDK23NS087151 · NINDS · STANFORD UNIVERSITY · PI VAN HAREN, KEITH · 2015 to 2019
$926k
Child Neurology Foundation Scientific AwardKenneth and Claudia Silverman Family Foundation N/AMontel Williams Foundation N/ANINDS NIH HHS K23 NS087151
6 · The paper itself

Abstract

Vitamin D is a steroid hormone that has been widely studied as a potential therapy for multiple sclerosis and other inflammatory disorders. Pre-clinical studies have implicated vitamin D in the transcription of thousands of genes, but its influence may vary by cell type. A handful of clinical studies have failed to identify an in vivo gene expression signature when using bulk analysis of all peripheral immune cells. We hypothesized that vitamin D's gene signature would vary by immune cell type, requiring the analysis of distinct cell types. Multiple sclerosis patients (

Indexed as

Multiple SclerosisVitamin DHumansLeukocytes, MononuclearMonocytesProspective StudiesT-LymphocytesTranscriptomeVitaminsVitamin DVitaminsB-cellsdifferentially expressed genesimmune cellsmicroarraymonocytesmultiple sclerosisT-cellsvitamin D

Identifiers

PMID36432424
PMCPMC9694020
OpenAlexW4308869080

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.