Evidence map›Paper›PMID 36432206›Full record

ArticleMolecules (Basel, Switzerland)2022

Fractionation and Extraction Optimization of Potentially Valuable Compounds and Their Profiling in Six Varieties of Two

Csaba Laszlo, Kacper Kaminski, Haifeng Guan, Maria Fatarova, Jianbing Wei, Alexandre Bergounioux, Walter K Schlage, Sandra Schorderet-Weber, Philippe A Guy, Nikolai V Ivanov and 2 more

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Csaba LaszloPMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000 Neuchâtel, Switzerland.ORCID 0000-0003-3078-3571
Kacper KaminskiPMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000 Neuchâtel, Switzerland.ORCID 0000-0003-0755-2740
Haifeng GuanNatural Product & Drug Discovery Department, Bicoll Biotechnology (Shanghai) Co., Ltd., Bibo Road 518, Zhangjiang Science City, Pudong, Shanghai 201203, China.
Maria FatarovaPMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000 Neuchâtel, Switzerland.
Jianbing WeiNatural Product & Drug Discovery Department, Bicoll Biotechnology (Shanghai) Co., Ltd., Bibo Road 518, Zhangjiang Science City, Pudong, Shanghai 201203, China.
Alexandre BergouniouxPMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000 Neuchâtel, Switzerland.
Walter K SchlageBiology Consultant, Max-Baermann-Str. 21, 51429 Bergisch Gladbach, Germany.
Sandra Schorderet-WeberPMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000 Neuchâtel, Switzerland.
Philippe A GuyPMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000 Neuchâtel, Switzerland.ORCID 0000-0002-2968-8625
Nikolai V IvanovPMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000 Neuchâtel, Switzerland.ORCID 0000-0002-2052-4333
Kai LamottkeBicoll GmbH, Am Klopferspitz 19, 82152 Planegg, Germany.ORCID 0000-0002-3265-1057
Julia HoengPMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000 Neuchâtel, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There is an increasingly urgent call to shift industrial processes from fossil fuel feedstock to sustainable bio-based resources. This change becomes of high importance considering new budget requirements for a carbon-neutral economy. Such a transformation can be driven by traditionally used plants that are able to produce large amounts of valuable biologically relevant secondary metabolites. Tobacco plants can play a leading role in providing value-added products in remote areas of the world. In this study, we propose a non-exhaustive list of compounds with potential economic interest that can be sourced from the tobacco plant. In order to optimize extraction methodologies, we first analyzed their physico-chemical properties using rapid solubility tests and high-resolution microfractionation techniques. Next, to identify an optimal extraction for a selected list of compounds, we compared 13 different extraction method-solvent combinations. We proceeded with profiling some of these compounds in a total of six varieties from

Indexed as

Chemical FractionationNicotianaNicotineNicotineextractionmicrofractionationNicotiana rusticaNicotiana tabacumpurification of plant compoundsvaluable compound profiling

Identifiers

PMID36432206
PMCPMC9694777

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.