Evidence map›Paper›PMID 36432194›Full record

ReviewMolecules (Basel, Switzerland)2022

Biotechnology and In Vitro Culture as an Alternative System for Secondary Metabolite Production.

Marouane Mohaddab, Younes El Goumi, Monica Gallo, Domenico Montesano, Gokhan Zengin, Abdelhakim Bouyahya, Malika Fakiri

Open access · goldAbstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
3.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 45 citations in OpenAlex.

  1. Polyphenol-Loaded Liposomal Nanocarriers fromMolecules (Basel, Switzerland) · 2026
    Article
  2. Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Molecules (Basel, Switzerland) · 2025
    Article
  9. Article
  10. Ethanolic extract ofFrontiers in plant science · 2025
    Article
  11. Review
  12. Article
  13. Review
  14. Suspension culture of somatic embryos for the production of high-value secondary metabolites.Physiology and molecular biology of plants : an international journal of functional plant biology · 2023
    Review
  15. Article
  16. Article
  17. Chinese olive (Frontiers in pharmacology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 3 countries.

Marouane MohaddabLaboratory of Agrifood and Health, Faculty of Sciences and Techniques, Hassan First University of Settat, BP 577, Settat 26000, Morocco.ORCID 0000-0002-7791-368X
Younes El GoumiPolyyvalent Team in R&D, Higher School of Technology of Fkih Ben Salah, Sultan Moulay Slimane University, USMS, Beni Mellal 23000, Morocco.ORCID 0000-0003-4812-9535
Monica GalloDepartment of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, via Pansini, 5, 80131 Naples, Italy.ORCID 0000-0001-6281-426X
Domenico MontesanoDepartment of Pharmacy, University of Naples Federico II, via D. Montesano 49, 80131 Naples, Italy.ORCID 0000-0002-8857-2091
Gokhan ZenginDepartment of Biology, Science Faculty, Selcuk University, Konya 42130, Turkey.ORCID 0000-0001-6548-7823
Abdelhakim BouyahyaLaboratory of Human Pathologies Biology, Department of Biology, Faculty of Sciences, Mohammed V University in Rabat, Rabat 10106, Morocco.
Malika FakiriLaboratory of Agrifood and Health, Faculty of Sciences and Techniques, Hassan First University of Settat, BP 577, Settat 26000, Morocco.
Université Hassan 1er · MAUniversity of Naples Federico II · ITMohammed V University · MASelçuk University · TRUniversité Sultan Moulay Slimane · MA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Medicinal plants are rich sources of bioactive compounds widely used as medicaments, food additives, perfumes, and agrochemicals. These secondary compounds are produced under stress conditions to carry out physiological tasks in plants. Secondary metabolites have a complex chemical structure with pharmacological properties. The widespread use of these metabolites in a lot of industrial sectors has raised the need to increase the production of secondary metabolites. Biotechnological methods of cell culture allow the conservation of plants, as well as the improvement of metabolite biosynthesis and the possibility to modify the synthesis pathways. The objective of this review is to outline the applications of different in vitro culture systems with previously reported relevant examples for the optimal production of plant-derived secondary metabolites.

Indexed as

BiotechnologyPlants, MedicinalBiosynthetic Pathwaysbiological effectscell cultureelicitorsecondary metabolites

Identifiers

PMID36432194
PMCPMC9697480
OpenAlexW4309717504

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.