Evidence map›Paper›PMID 36432169›Full record

ArticleMolecules (Basel, Switzerland)2022

Arteannuin-B and (3-Chlorophenyl)-2-Spiroisoxazoline Derivative Exhibit Anti-Inflammatory Effects in LPS-Activated RAW 264.7 Macrophages and BALB/c Mice-Induced Proinflammatory Responses via Downregulation of NF-κB/P38 MAPK Signaling.

Gifty Sawhney, Javeed Ur Rasool, Diksha Saroch, Mumin Ozturk, Frank Brombacher, Bilal Ahmad, Asha Bhagat, Asif Ali, Suraj P Parihar, Zabeer Ahmed

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Anti-inflammatory and anticancer properties ofFrontiers in pharmacology · 2025
    Article
  3. Journal of experimental pharmacology · 2025
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 3 countries.

Gifty SawhneyPharmacology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India.ORCID 0000-0003-3003-9179
Javeed Ur RasoolAcademy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India.
Diksha SarochPharmacology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India.
Mumin OzturkInternational Centre for Genetic Engineering and Biotechnology (ICGEB), Cape Town 7925, South Africa.ORCID 0000-0001-9152-7614
Frank BrombacherInternational Centre for Genetic Engineering and Biotechnology (ICGEB), Cape Town 7925, South Africa.
Bilal AhmadDepartment of Molecular Science and Technology, Ajou University, Suwon 16499, Republic of Korea.
Asha BhagatPharmacology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India.
Asif AliAcademy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India.
Suraj P PariharInternational Centre for Genetic Engineering and Biotechnology (ICGEB), Cape Town 7925, South Africa.ORCID 0000-0002-4932-7990
Zabeer AhmedPharmacology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India.
Indian Institute of Integrative Medicine · INUniversity of Cape Town · ZAAjou University · KRInstitute of Genomics and Integrative Biology · INInternational Centre for Genetic Engineering and Biotechnology · ZA

Funding

Department of Science and Technology IF 2017-170212International Centre for Genetic Engineering and Biotechnology F/IND 19-11
6 · The paper itself

Abstract

Host inflammatory responses are key to protection against injury; however, persistent inflammation is detrimental and contributes to morbidity and mortality. Herein, we demonstrated the anti-inflammatory role of Arteannuin-B (

Indexed as

LipopolysaccharidesNF-kappa BAnimalsAnti-Inflammatory AgentsArtemisininsDown-RegulationMacrophagesMiceMice, Inbred BALB Cp38 Mitogen-Activated Protein KinasesAnti-Inflammatory Agentsarteannuin BartemisininArtemisininsLipopolysaccharidesNF-kappa Bp38 Mitogen-Activated Protein KinasesArteannuin-BBALB/c micecytokinesIL-6inflammationiNOSLPSNF-κBRAW 264.7 cellsspirocyclic-2-isoxazoline derivativeTNF-α

Identifiers

PMID36432169
PMCPMC9699497
OpenAlexW4309743921

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.