Evidence map›Paper›PMID 36432107›Full record

ReviewMolecules (Basel, Switzerland)2022

Future Prospective of Radiopharmaceuticals from Natural Compounds Using Iodine Radioisotopes as Theranostic Agents.

Wiwit Nurhidayah, Luthfi Utami Setyawati, Isti Daruwati, Amirah Mohd Gazzali, Toto Subroto, Muchtaridi Muchtaridi

Open access · goldAbstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

  1. Hyaluronic acid-modified polymeric nanoplatform deliveringJournal of pharmaceutical analysis · 2026
    Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. A Perspective on Production and Quality Control of Iodine-123 Radiopharmaceutical for Applications in Nuclear Medicine.Indian journal of nuclear medicine : IJNM : the official journal of the Society of Nuclear Medicine, India
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Wiwit NurhidayahDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Padjadjaran University, Sumedang 45363, Indonesia.
Luthfi Utami SetyawatiDepartment of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Padjadjaran University, Sumedang 45363, Indonesia.
Isti DaruwatiResearch Collaboration Centre for Theranostic Radiopharmaceuticals, National Research and Innovation Agency (BRIN), Sumedang 45363, Indonesia.
Amirah Mohd GazzaliSchool of Pharmaceutical Sciences, Universiti Sains Malaysia, USM, Penang 11800, Malaysia.ORCID 0000-0003-4469-1969
Toto SubrotoDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Padjadjaran University, Sumedang 45363, Indonesia.
Muchtaridi MuchtaridiDepartment of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Padjadjaran University, Sumedang 45363, Indonesia.ORCID 0000-0002-6156-8025
National Research and Innovation Agency · IDPadjadjaran University · IDNational Nuclear Energy Agency of Indonesia · IDUniversiti Sains Malaysia · MY

Funding

PMDSU Scholarship 1347/UN6.3.1/PT.00/2021
6 · The paper itself

Abstract

Natural compounds provide precursors with various pharmacological activities and play an important role in discovering new chemical entities, including radiopharmaceuticals. In the development of new radiopharmaceuticals, iodine radioisotopes are widely used and interact with complex compounds including natural products. However, the development of radiopharmaceuticals from natural compounds with iodine radioisotopes has not been widely explored. This review summarizes the development of radiopharmaceuticals from natural compounds using iodine radioisotopes in the last 10 years, as well as discusses the challenges and strategies to improve future discovery of radiopharmaceuticals from natural resources. Literature research was conducted via PubMed, from which 32 research articles related to the development of natural compounds labeled with iodine radioisotopes were reported. From the literature, the challenges in developing radiopharmaceuticals from natural compounds were the purity and biodistribution. Despite the challenges, the development of radiopharmaceuticals from natural compounds is a golden opportunity for nuclear medicine advancement.

Indexed as

Iodine RadioisotopesRadiopharmaceuticalsPrecision MedicineRadionuclide ImagingTissue DistributionIodine RadioisotopesRadiopharmaceuticalsiodine radioisotopesnatural compoundsradiopharmaceuticals

Identifiers

PMID36432107
PMCPMC9694974
OpenAlexW4309461378

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.