Evidence map›Paper›PMID 36432043›Full record

ArticleMolecules (Basel, Switzerland)2022

Inhibitory Effect of Curcumin-Inspired Derivatives on Tyrosinase Activity and Melanogenesis.

Gaia Rocchitta, Carla Rozzo, Marina Pisano, Davide Fabbri, Maria Antonietta Dettori, Paolo Ruzza, Claudia Honisch, Roberto Dallocchio, Alessandro Dessì, Rossana Migheli and 2 more

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Green Extraction of Bioactives fromPlants (Basel, Switzerland) · 2025
    Article
  2. Antibiotics (Basel, Switzerland) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Gaia RocchittaDipartimento di Medicina, Chirurgia e Farmacia, Università Degli Studi di Sassari, 07100 Sassari, Italy.ORCID 0000-0002-4319-4197
Carla RozzoIstituto di Ricerca Genetica e Biomedica, Consiglio Nazionale Ricerche, 07100 Sassari, Italy.ORCID 0000-0001-6581-2227
Marina PisanoIstituto di Ricerca Genetica e Biomedica, Consiglio Nazionale Ricerche, 07100 Sassari, Italy.ORCID 0000-0002-0649-1010
Davide FabbriIstituto di Chimica Biomolecolare, Consiglio Nazionale Ricerche, 07100 Sassari, Italy.ORCID 0000-0002-3947-5164
Maria Antonietta DettoriIstituto di Chimica Biomolecolare, Consiglio Nazionale Ricerche, 07100 Sassari, Italy.ORCID 0000-0002-8776-9271
Paolo RuzzaIstituto di Chimica Biomolecolare, Consiglio Nazionale Ricerche, 35131 Padova, Italy.ORCID 0000-0002-5596-9295
Claudia HonischIstituto di Chimica Biomolecolare, Consiglio Nazionale Ricerche, 35131 Padova, Italy.
Roberto DallocchioIstituto di Chimica Biomolecolare, Consiglio Nazionale Ricerche, 07100 Sassari, Italy.ORCID 0000-0003-4626-4792
Alessandro DessìIstituto di Chimica Biomolecolare, Consiglio Nazionale Ricerche, 07100 Sassari, Italy.ORCID 0000-0001-8258-7332
Rossana MigheliDipartimento di Medicina, Chirurgia e Farmacia, Università Degli Studi di Sassari, 07100 Sassari, Italy.
PierAndrea SerraDipartimento di Medicina, Chirurgia e Farmacia, Università Degli Studi di Sassari, 07100 Sassari, Italy.
Giovanna DeloguIstituto di Chimica Biomolecolare, Consiglio Nazionale Ricerche, 07100 Sassari, Italy.
Istituto di Chimica Biomolecolare · ITUniversity of Sassari · ITInstitute of Genetic and Biomedical Research · IT

Funding

Sardinia Autonomous Region, project COSMESAGRO, L.R. 7, 2007 CRP 25,114
6 · The paper itself

Abstract

Tyrosinase is a well-known copper-containing metalloenzyme typically involved in the synthesis of melanin. Recently, curcumin and several synthetic derivatives have been recognized as tyrosinase inhibitors with interesting anti-melanogenic therapeutic activity. In this study, three curcumin-inspired compounds

Indexed as

CurcuminMonophenol MonooxygenaseAnimalsArbutinHumansHydrogen PeroxideMelaninsMolecular Docking SimulationRatsArbutinCurcuminHydrogen PeroxideMelaninsMonophenol Monooxygenaseantioxidant activitybiosensorscurcumin-inspired derivativeshyperpigmentationin silico analysesmelanogenesissustainable synthesistyrosinase inhibitors

Identifiers

PMID36432043
PMCPMC9695798
OpenAlexW4309721393

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.