Evidence map›Paper›PMID 36431955›Full record

ArticleMolecules (Basel, Switzerland)2022

Therapeutic Potential of 2-Methylquinazolin-4(3H)-one as an Antiviral Agent against Influenza A Virus-Induced Acute Lung Injury in Mice.

Rong Tian, Haiyan Zhu, Yan Lu, Xunlong Shi, Peng Tu, Hong Li, Hai Huang, Daofeng Chen

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Rong TianDepartment of Natural Medicine, School of Pharmacy, Fudan University, No. 3728, Jin Ke Road, Shanghai 201203, China.ORCID 0000-0003-2992-3098
Haiyan ZhuDepartment of Biological Medicines & Shanghai Engineering Research Center of Immunotherapeutics, School of Pharmacy, Fudan University, No. 3728, Jin Ke Road, Shanghai 201203, China.ORCID 0000-0002-8109-6678
Yan LuDepartment of Natural Medicine, School of Pharmacy, Fudan University, No. 3728, Jin Ke Road, Shanghai 201203, China.ORCID 0000-0002-9420-7090
Xunlong ShiDepartment of Biological Medicines & Shanghai Engineering Research Center of Immunotherapeutics, School of Pharmacy, Fudan University, No. 3728, Jin Ke Road, Shanghai 201203, China.
Peng TuDepartment of Natural Medicine, School of Pharmacy, Fudan University, No. 3728, Jin Ke Road, Shanghai 201203, China.
Hong LiDepartment of Pharmacy, Fudan University, No. 3728, Jin Ke Road, Shanghai 201203, China.ORCID 0000-0002-4339-3866
Hai HuangDepartment of Biological Medicines & Shanghai Engineering Research Center of Immunotherapeutics, School of Pharmacy, Fudan University, No. 3728, Jin Ke Road, Shanghai 201203, China.
Daofeng ChenDepartment of Natural Medicine, School of Pharmacy, Fudan University, No. 3728, Jin Ke Road, Shanghai 201203, China.
Fudan University · CN

Funding

National Key R&D Program of China 2019YFC 1711000National Natural Science Foundation of China 81330089
6 · The paper itself

Abstract

Qingdai-Mabo (QM), a traditional Chinese herbal formula composed of medicinal herb and fungus, has been used for treatment of cough and viral pneumonia. However, the underlying mechanism and bioactive components against anti-influenza A virus remain unclear. In the present study, ethyl acetate (EA) extract of QM decoctions was tested for its biological activity against acute lung injury (ALI) and its main components were identified using UPLC-MS/MS. In total, 18 bioactive components were identified, including 2-Methylquinaozlin-4(3H)-one (C1), which showed significant antiviral activity in vitro with an IC

Indexed as

Acute Lung InjuryInfluenza A virusInfluenza A Virus, H1N1 SubtypePneumonia, ViralAnimalsAntiviral AgentsChromatography, LiquidInflammationMicePlant ExtractsTandem Mass SpectrometryAntiviral AgentsPlant Extracts2-Methylquinazolin-4(3H)-oneacute lung injuryantiviral activityinfluenza A virusQingdai-Maboviral pneumonia

Identifiers

PMID36431955
PMCPMC9697438
OpenAlexW4309739358

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.