Evidence map›Paper›PMID 36431920›Full record

ArticleMolecules (Basel, Switzerland)2022

Catalytic Enantioselective Synthesis of N-C Axially Chiral

Sota Fukasawa, Tatsuya Toyoda, Ryohei Kasahara, Chisato Nakamura, Yuuki Kikuchi, Akiko Hori, Gary J Richards, Osamu Kitagawa

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Sota FukasawaDepartment of Applied Chemistry (Japanese Association of Bio-Intelligence for Well-Being), Shibaura Institute of Technology, 3-7-5 Toyosu, Kohto-ku, Tokyo 135-8548, Japan.
Tatsuya ToyodaDepartment of Applied Chemistry (Japanese Association of Bio-Intelligence for Well-Being), Shibaura Institute of Technology, 3-7-5 Toyosu, Kohto-ku, Tokyo 135-8548, Japan.
Ryohei KasaharaDepartment of Applied Chemistry (Japanese Association of Bio-Intelligence for Well-Being), Shibaura Institute of Technology, 3-7-5 Toyosu, Kohto-ku, Tokyo 135-8548, Japan.
Chisato NakamuraDepartment of Applied Chemistry (Japanese Association of Bio-Intelligence for Well-Being), Shibaura Institute of Technology, 3-7-5 Toyosu, Kohto-ku, Tokyo 135-8548, Japan.
Yuuki KikuchiDepartment of Applied Chemistry (Japanese Association of Bio-Intelligence for Well-Being), Shibaura Institute of Technology, 3-7-5 Toyosu, Kohto-ku, Tokyo 135-8548, Japan.
Akiko HoriGraduate School of Engineering and Science, Shibaura Institute of Technology, 307 Fukasaku, Minuma-ku, Saitama 337-8570, Japan.ORCID 0000-0002-0969-8500
Gary J RichardsGraduate School of Engineering and Science, Shibaura Institute of Technology, 307 Fukasaku, Minuma-ku, Saitama 337-8570, Japan.
Osamu KitagawaDepartment of Applied Chemistry (Japanese Association of Bio-Intelligence for Well-Being), Shibaura Institute of Technology, 3-7-5 Toyosu, Kohto-ku, Tokyo 135-8548, Japan.ORCID 0000-0001-7964-1879
Shibaura Institute of Technology · JP

Funding

Japan Society for the Promotion of Science C 20K06945
6 · The paper itself

Abstract

Recently, catalytic enantioselective syntheses of N-C axially chiral compounds have been reported by many groups. Most N-C axially chiral compounds prepared through a catalytic asymmetric reaction possess carboxamide or nitrogen-containing aromatic heterocycle skeletons. On the other hand, although N-C axially chiral sulfonamide derivatives are known, their catalytic enantioselective synthesis is relatively underexplored. We found that the reaction (Tsuji-Trost allylation) of allyl acetate with secondary sulfonamides bearing a 2-arylethynyl-6-methylphenyl group on the nitrogen atom proceeds with good enantioselectivity (up to 92% ee) in the presence of (

Indexed as

PalladiumSulfonamidesCatalysisNitrogenStereoisomerismSulfanilamideNitrogenPalladiumSulfanilamideSulfonamidesasymmetric catalystatropisomersaxial chiralityN-allylationpalladiumsulfonamides

Identifiers

PMID36431920
PMCPMC9698006
OpenAlexW4308975280

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.