Evidence map›Paper›PMID 36431910›Full record

ArticleMolecules (Basel, Switzerland)2022

Using the Intrinsic Fluorescence of DNA to Characterize Aptamer Binding.

Chang Lu, Anand Lopez, Jinkai Zheng, Juewen Liu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Quenching of G4-DNA intrinsic fluorescence by ligands.European biophysics journal : EBJ · 2024
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Chang LuInstitute of Food Science and Technology, Chinese Academy of Agricultural Sciences, Beijing 100193, China.ORCID 0000-0002-7585-2473
Anand LopezDepartment of Chemistry, Waterloo Institute for Nanotechnology, University of Waterloo, Waterloo, ON N2L 3G1, Canada.
Jinkai ZhengInstitute of Food Science and Technology, Chinese Academy of Agricultural Sciences, Beijing 100193, China.
Juewen LiuDepartment of Chemistry, Waterloo Institute for Nanotechnology, University of Waterloo, Waterloo, ON N2L 3G1, Canada.ORCID 0000-0001-5918-9336
University of Waterloo · CAInstitute of Food Science and Technology · CN

Funding

Agricultural Science and Technology Innovation Program CAAS-ASTIP-2021-IFST-SN2021-05China Scholarship Council N/ANational Natural Science Foundation of China 31901776 and 32072181Natural Sciences and Engineering Research Council N/A
6 · The paper itself

Abstract

The reliable, readily accessible and label-free measurement of aptamer binding remains a challenge in the field. Recent reports have shown large changes in the intrinsic fluorescence of DNA upon the formation of G-quadruplex and i-motif structures. In this work, we examined whether DNA intrinsic fluorescence can be used for studying aptamer binding. First, DNA hybridization resulted in a drop in the fluorescence, which was observed for A30/T30 and a 24-mer random DNA sequence. Next, a series of DNA aptamers were studied. Cortisol and Hg

Indexed as

Aptamers, NucleotideG-QuadruplexesDNAHydrocortisoneNucleic Acid HybridizationAptamers, NucleotideDNAHydrocortisoneaptamerbindingDNAintrinsic fluorescence

Identifiers

PMID36431910
PMCPMC9692703
OpenAlexW4309012698

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.