Evidence map›Paper›PMID 36431814›Full record

ArticleMolecules (Basel, Switzerland)2022

Optimization of κ-Selenocarrageenase Production by

Yashan Deng, Xixi Wang, Hui Xu, Cui Liu, Ran Li, Yuanyuan Zhang, Changfeng Qu, Jinlai Miao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Yashan DengDepartment of Pharmaceutical Engineering, College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao 266042, China.
Xixi WangKey Laboratory of Marine Eco-Environmental Science and Technology, First Institute of Oceanography, Ministry of Natural Resources, Qingdao 266061, China.
Hui XuDepartment of Pharmaceutical Engineering, College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao 266042, China.
Cui LiuDepartment of Pharmaceutical Engineering, College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao 266042, China.
Ran LiDepartment of Pharmaceutical Engineering, College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao 266042, China.
Yuanyuan ZhangDepartment of Pharmaceutical Engineering, College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao 266042, China.
Changfeng QuKey Laboratory of Marine Eco-Environmental Science and Technology, First Institute of Oceanography, Ministry of Natural Resources, Qingdao 266061, China.
Jinlai MiaoKey Laboratory of Marine Eco-Environmental Science and Technology, First Institute of Oceanography, Ministry of Natural Resources, Qingdao 266061, China.
Qingdao University of Science and Technology · CNFirst Institute of Oceanography · CNMinistry of Natural Resources · CNQingdao National Laboratory for Marine Science and Technology · CN

Funding

National Natural Science Foundation of China 32000074National Natural Science Foundation of China 42176130Natural Science Foundation of Shandong ZR2021MD044Tai Mountain Industry Leading Talent of Shandong 2019TSCYCX-06
6 · The paper itself

Abstract

The bioenzymatic production of selenium oligosaccharides addresses the problems resulting from high molecular weight and poor water solubility of κ-selenocarrageenan, and lays foundation for its application as adjuvant drugs for cancer treatment and food additive. κ-selenocarrageenase extracted from Pseudoalteromonas sp. Xi13 can degrade κ-selenocarrageenan to selenium oligosaccharides. The maximum optimized κ-selenocarrageenase activity using Response Surface Methodology (RSM) was increased by 1.4 times, reaching 8.416 U/mL. To expand applications of the κ-selenocarrageenase in industry, the preparation conditions of it in either lyophilized or immobilized form were investigated. The activity recovery rate of the lyophilized enzyme was >70%, while that of the immobilized enzyme was 62.83%. However, the immobilized κ-selenocarrageenase exhibits good stability after being reused four times, with 58.28% of residual activity. The selenium content of κ-selenocarrageenan oligosaccharides degraded by the immobilized κ-selenocarrageenase was 47.06 µg/g, 8.3% higher than that degraded by the lyophilized enzyme. The results indicate that the immobilized κ-selenocarrageenase is suitable for industrial applications and has commercial potential.

Indexed as

Organoselenium CompoundsPseudoalteromonasSeleniumCarrageenanCarrageenankappa-selenocarrageenanOrganoselenium CompoundsSeleniumimmobilized enzymelyophilized enzymePseudoalteromonas sp. Xi13selenium oligosaccharidesκ-selenocarrageenase

Identifiers

PMID36431814
PMCPMC9694495
OpenAlexW4309520112

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.