Evidence map›Paper›PMID 36431789›Full record

ArticleMolecules (Basel, Switzerland)2022

Integrated Solid-Phase Extraction, Ultra-High-Performance Liquid Chromatography-Quadrupole-Orbitrap High-Resolution Mass Spectrometry, and Multidimensional Data-Mining Techniques to Unravel the Metabolic Network of Dehydrocostus Lactone in Rats.

Yingying Tian, Beibei Ma, Chuang Liu, Xinyue Zhao, Shangyue Yu, Yilin Li, Shiqiu Tian, Hailuan Pei, Zijian Wang, Zeping Zuo and 1 more

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Yingying TianSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, China.
Beibei MaResearch Institute of Beijing Tongrentang Co., Ltd., Beijing 100079, China.ORCID 0000-0002-4235-0792
Chuang LiuSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, China.
Xinyue ZhaoSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, China.
Shangyue YuSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, China.
Yilin LiSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, China.
Shiqiu TianSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, China.
Hailuan PeiSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, China.
Zijian WangResearch Institute of Beijing Tongrentang Co., Ltd., Beijing 100079, China.
Zeping ZuoResearch Institute of Beijing Tongrentang Co., Ltd., Beijing 100079, China.
Zhibin WangSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, China.ORCID 0000-0003-3091-0921
Beijing University of Chinese Medicine · CNBeijing Tongren Hospital · CN

Funding

National Science and Technology Major Project 2018ZX09201-011National Science and Technology Major Project 2018ZX09301-011-003
6 · The paper itself

Abstract

Dehydrocostus lactone (DL) is among the representative ingredients of traditional Chinese medicine (TCM), with excellent anticancer, antibacterial, and anti-inflammatory activities. In this study, an advanced strategy based on ultra-high-performance liquid chromatography-quadrupole-Orbitrap high-resolution mass spectrometry (UHPLC-Q-Orbitrap HRMS) was integrated to comprehensively explore the metabolic fate of DL in rats. First, prior to data collection, all biological samples (plasma, urine, and feces) were concentrated and purified using solid-phase extraction (SPE) pre-treatment technology. Then, during data collection, in the full-scan (FS) data-dependent acquisition mode, FS-ddMS

Indexed as

Metabolic Networks and PathwaysSolid Phase ExtractionAnimalsChromatography, High Pressure LiquidData MiningLactonesMass SpectrometryRatsSesquiterpenesdehydrocostus lactoneLactonesSesquiterpenesdata-mining techniquesdehydrocostus lactone (DL)metabolic networksolid-phase extraction (SPE)UHPLC–Q-Orbitrap HRMS

Identifiers

PMID36431789
PMCPMC9696973
OpenAlexW4308720496

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.