ArticleMaterials (Basel, Switzerland)2022
Quantification of Microstructural Changes in the Dermis of Elderly Women Using Morphometric Indices of the Skin Surface.
Article in Materials (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 4 citations in OpenAlex.
- Estimation of skin surface roughnessFrontiers in medicine · 2024Article
- In Vivo Assessment of Skin Surface Pattern: Exploring Its Potential as an Indicator of Bone Biomechanical Properties.Bioengineering (Basel, Switzerland) · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe main objective of this study was the development of a non-invasive mathematical marker of the skin surface, the characteristic length, to predict the microstructure of the dermis. This marker, at the individual level, is intended to provide the biological age of the patient in the context of personalised medicine for the elderly. STUDY
designTo validate this hypothesis, a clinical study was conducted on 22 women over 60 years old from a population of osteoporotic subjects who sustained a femoral neck fracture: a morphological analysis of the skin surface was performed on the patient's forearm and quantitatively compared with microarchitectural parameters of the dermis. MAJOR
resultsThe Elastin-to-Collagen ratio measured on dermis samples ranged between 0.007 and 0.084, with a mean of 0.035 ± 0.02. The surface characteristic length ranged between 0.90 and 2.621, with a mean of 0.64 ± 0.51. A very strong correlation was found between this characteristic length and the Elastin-to-Collagen ratio (r = 0.92).
conclusionsThis study proposes an original diagnostic tool based on morphometric indices of the skin surface and shows a direct quantitative relationship with the dermis microarchitecture and its collagen and elastin content. The proposed method allows reliable and easy access to the intrinsic ageing of the dermis, which would be a strong biomarker in a personalised collagen treatment approach.
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Registered trials
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