Evidence map›Paper›PMID 36431335›Full record

ArticleJournal of clinical medicine2022

Childhood Pemphigus Vulgaris during COVID-19 Outbreak Successfully Treated with Prednisone and Azathioprine: A Case Report and Literature Review.

Pamela Vezzoli, Michele Parietti, Andrea Carugno, Marco Di Mercurio, Chiara Benaglia, Martina Zussino, Riccardo Cavalli, Paolo Sena, Emilio Berti

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Pamela VezzoliDermatology Unit, ASST Papa Giovanni XXIII Hospital, 24127 Bergamo, Italy.
Michele PariettiDermatology Unit, ASST Papa Giovanni XXIII Hospital, 24127 Bergamo, Italy.ORCID 0000-0003-4673-4635
Andrea CarugnoDermatology Unit, ASST Papa Giovanni XXIII Hospital, 24127 Bergamo, Italy.ORCID 0000-0002-8231-2205
Marco Di MercurioDermatology Unit, ASST Papa Giovanni XXIII Hospital, 24127 Bergamo, Italy.
Chiara BenagliaDermatology Unit, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Università degli Studi di Milano, 20122 Milan, Italy.ORCID 0000-0003-0279-277X
Martina ZussinoDermatology Unit, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Università degli Studi di Milano, 20122 Milan, Italy.
Riccardo CavalliPediatric Dermatology, Foundation IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Università degli Studi di Milano, 20122 Milan, Italy.
Paolo SenaDermatology Unit, ASST Papa Giovanni XXIII Hospital, 24127 Bergamo, Italy.
Emilio BertiDermatology Unit, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Università degli Studi di Milano, 20122 Milan, Italy.ORCID 0000-0001-6753-4910
Ospedale Papa Giovanni XXIII · ITUniversity of Milan · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionpemphigus vulgaris is a rare autoimmune blistering disease that involves the skin and mucous membranes and rarely occurs in pediatric age.

methodswe present a case of childhood pemphigus in a 9-year-old patient from Burkina Faso, which initially manifested with erosive lesions symmetrically distributed in the oral cavity. After a few months, we also observed hyperchromic lesions of the back. Histopathological examination of skin samples showed intraepidermal acantholysis, while direct immunofluorescence showed deposits of complement (C3) and immunoglobulins G (IgG) in the epidermidis; an ELISA test highlighted the presence of circulating autoantibodies against desmoglein 3.

resultsthe follow-up of this patient was made difficult by the advent of the COVID-19 outbreak. However, after about one year of combined therapy with systemic steroids and azathioprine the patient reached clinical remission.

Indexed as

autoimmune blistering diseasechildhood pemphigusimmunosuppressive therapy

Identifiers

PMID36431335
PMCPMC9696635
OpenAlexW4309787091

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.